Cargando…

Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser

Photothermal therapy (PTT) is widely regarded as a promising technology for cancer treatment. Gold nanorods (GNRs), as excellent PTT agent candidates, have shown high-performance photothermal conversion ability under laser irradiation, yet two major obstacles to their clinical application are the la...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yang, Xu, Ming, Chen, Qing, Guan, Guannan, Hu, Wen, Zhao, Xiuli, Qiao, Mingxi, Hu, Haiyang, Liang, Ying, Zhu, Heyun, Chen, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524460/
https://www.ncbi.nlm.nih.gov/pubmed/26251596
http://dx.doi.org/10.2147/IJN.S82940
_version_ 1782384200072036352
author Liu, Yang
Xu, Ming
Chen, Qing
Guan, Guannan
Hu, Wen
Zhao, Xiuli
Qiao, Mingxi
Hu, Haiyang
Liang, Ying
Zhu, Heyun
Chen, Dawei
author_facet Liu, Yang
Xu, Ming
Chen, Qing
Guan, Guannan
Hu, Wen
Zhao, Xiuli
Qiao, Mingxi
Hu, Haiyang
Liang, Ying
Zhu, Heyun
Chen, Dawei
author_sort Liu, Yang
collection PubMed
description Photothermal therapy (PTT) is widely regarded as a promising technology for cancer treatment. Gold nanorods (GNRs), as excellent PTT agent candidates, have shown high-performance photothermal conversion ability under laser irradiation, yet two major obstacles to their clinical application are the lack of selective accumulation in the target site following systemic administration and the greatly reduced photothermal conversion efficiency caused by self-aggregating in aqueous environment. Herein, we demonstrate that tLyp-1 peptide-functionalized, indocyanine green (ICG)-containing mesoporous silica-coated GNRs (I-TMSG) possessed dual-function as tumor cells-targeting near-infrared (NIR) fluorescent probe and PTT agents. The construction of the nanostructure began with synthesis of GNRs by seed-mediated growth method, followed by the coating of mesoporous silica, the chemical conjugation of PEG and tLyp-1 peptide, and the enclosure of ICG as an NIR imaging agent in the mesoporous. The as-prepared nanoparticles could shield the GNRs against their self-aggregation, improve the stability of ICG, and exhibit negligible dark cytotoxicity. More importantly, such a theranostic nanocomposite could realize the combination of GNRs-based photothermal ablation under NIR illumination, ICG-mediated fluorescent imaging, and tLyp-1-enabled more easy endocytosis into breast cancer cells. All in all, I-TMSG nanoparticles, in our opinion, possessed the strong potential to realize the effective diagnosis and PTT treatment of human mammary cancer.
format Online
Article
Text
id pubmed-4524460
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-45244602015-08-06 Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser Liu, Yang Xu, Ming Chen, Qing Guan, Guannan Hu, Wen Zhao, Xiuli Qiao, Mingxi Hu, Haiyang Liang, Ying Zhu, Heyun Chen, Dawei Int J Nanomedicine Original Research Photothermal therapy (PTT) is widely regarded as a promising technology for cancer treatment. Gold nanorods (GNRs), as excellent PTT agent candidates, have shown high-performance photothermal conversion ability under laser irradiation, yet two major obstacles to their clinical application are the lack of selective accumulation in the target site following systemic administration and the greatly reduced photothermal conversion efficiency caused by self-aggregating in aqueous environment. Herein, we demonstrate that tLyp-1 peptide-functionalized, indocyanine green (ICG)-containing mesoporous silica-coated GNRs (I-TMSG) possessed dual-function as tumor cells-targeting near-infrared (NIR) fluorescent probe and PTT agents. The construction of the nanostructure began with synthesis of GNRs by seed-mediated growth method, followed by the coating of mesoporous silica, the chemical conjugation of PEG and tLyp-1 peptide, and the enclosure of ICG as an NIR imaging agent in the mesoporous. The as-prepared nanoparticles could shield the GNRs against their self-aggregation, improve the stability of ICG, and exhibit negligible dark cytotoxicity. More importantly, such a theranostic nanocomposite could realize the combination of GNRs-based photothermal ablation under NIR illumination, ICG-mediated fluorescent imaging, and tLyp-1-enabled more easy endocytosis into breast cancer cells. All in all, I-TMSG nanoparticles, in our opinion, possessed the strong potential to realize the effective diagnosis and PTT treatment of human mammary cancer. Dove Medical Press 2015-07-28 /pmc/articles/PMC4524460/ /pubmed/26251596 http://dx.doi.org/10.2147/IJN.S82940 Text en © 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Liu, Yang
Xu, Ming
Chen, Qing
Guan, Guannan
Hu, Wen
Zhao, Xiuli
Qiao, Mingxi
Hu, Haiyang
Liang, Ying
Zhu, Heyun
Chen, Dawei
Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title_full Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title_fullStr Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title_full_unstemmed Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title_short Gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
title_sort gold nanorods/mesoporous silica-based nanocomposite as theranostic agents for targeting near-infrared imaging and photothermal therapy induced with laser
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524460/
https://www.ncbi.nlm.nih.gov/pubmed/26251596
http://dx.doi.org/10.2147/IJN.S82940
work_keys_str_mv AT liuyang goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT xuming goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT chenqing goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT guanguannan goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT huwen goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT zhaoxiuli goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT qiaomingxi goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT huhaiyang goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT liangying goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT zhuheyun goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser
AT chendawei goldnanorodsmesoporoussilicabasednanocompositeastheranosticagentsfortargetingnearinfraredimagingandphotothermaltherapyinducedwithlaser