Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages

Nuclear receptor Nur77, also referred to as NR4A1 or TR3, plays an important role in innate and adaptive immunity. Nur77 is crucial in regulating the T helper 1/regulatory T-cell balance, is expressed in macrophages and drives M2 macrophage polarization. In this study we aimed to define the function...

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Detalles Bibliográficos
Autores principales: Hamers, Anouk A. J., van Dam, Laura, Teixeira Duarte, José M., Vos, Mariska, Marinković, Goran, van Tiel, Claudia M., Meijer, Sybren L., van Stalborch, Anne-Marieke, Huveneers, Stephan, te Velde, Anje A., de Jonge, Wouter J., de Vries, Carlie J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524678/
https://www.ncbi.nlm.nih.gov/pubmed/26241646
http://dx.doi.org/10.1371/journal.pone.0133598

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