Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neurito...

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Detalles Bibliográficos
Autores principales: Alleaume-Butaux, Aurélie, Nicot, Simon, Pietri, Mathéa, Baudry, Anne, Dakowski, Caroline, Tixador, Philippe, Ardila-Osorio, Hector, Haeberlé, Anne-Marie, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524729/
https://www.ncbi.nlm.nih.gov/pubmed/26241960
http://dx.doi.org/10.1371/journal.ppat.1005073

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