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Immunity to tetanus in major beta thalassemia patients

PURPOSE: Patients with beta thalassemia major are at increased risk for bacterial infections specially splenectomized patients. The aim of this study was to determine the anti-tetanus antibody concentration among patients with beta thalassemia major. MATERIALS AND METHODS: The anti-tetanus antibody...

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Autores principales: Jahromi, Abdolreza Sotoodeh, Rahmanian, Karamatollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524903/
https://www.ncbi.nlm.nih.gov/pubmed/26273577
http://dx.doi.org/10.7774/cevr.2015.4.2.184
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author Jahromi, Abdolreza Sotoodeh
Rahmanian, Karamatollah
author_facet Jahromi, Abdolreza Sotoodeh
Rahmanian, Karamatollah
author_sort Jahromi, Abdolreza Sotoodeh
collection PubMed
description PURPOSE: Patients with beta thalassemia major are at increased risk for bacterial infections specially splenectomized patients. The aim of this study was to determine the anti-tetanus antibody concentration among patients with beta thalassemia major. MATERIALS AND METHODS: The anti-tetanus antibody concentration was investigated in 224 patients with thalassemia major and 224 healthy subjects matched for age and gender. Tetanus antibody and ferritin serum level were determined by enzyme-linked immunosorbent assay method using commercial kits. Subjects who had antibody level ≥ 0.1 IU/mL was defined as complete protection, 0.01 to < 0.1 IU/mL as partial protection and < 0.01 IU/mL as no protection. For the analysis, we used SPSS version 11.5 software. A two-sided p-value less 0.05 was considered statistically significant. RESULTS: In patients with beta thalassemia major, antibody level against tetanus was inversely dependent about 29.3% to serum ferritin level. Thus, when serum ferritin increased 1 ng/mL, serum antibody against tetanus decreased 0.002 IU/mL. Mean anti-tetanus (IgG) antibody titers was lower in thalassemia patients compared to healthy subjects (1.53 ± 1.71 vs. 2.02 ± 2.05, p = 0.007) that was no significantly associated to age and gender in both study groups. All of participants had serum antibody level 0.01 IU/mL or greater. The complete protective level of anti-tetanus antibody was lower in thalassemia subjects in compare to healthy persons (71% vs. 87.9%, p < 0.001). CONCLUSION: Patients with thalassemia had lower anti-tetanus antibody level than healthy subjects. Thus the vaccine recommendation seems essential for patients with beta thalassemia major.
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spelling pubmed-45249032015-08-13 Immunity to tetanus in major beta thalassemia patients Jahromi, Abdolreza Sotoodeh Rahmanian, Karamatollah Clin Exp Vaccine Res Original Article PURPOSE: Patients with beta thalassemia major are at increased risk for bacterial infections specially splenectomized patients. The aim of this study was to determine the anti-tetanus antibody concentration among patients with beta thalassemia major. MATERIALS AND METHODS: The anti-tetanus antibody concentration was investigated in 224 patients with thalassemia major and 224 healthy subjects matched for age and gender. Tetanus antibody and ferritin serum level were determined by enzyme-linked immunosorbent assay method using commercial kits. Subjects who had antibody level ≥ 0.1 IU/mL was defined as complete protection, 0.01 to < 0.1 IU/mL as partial protection and < 0.01 IU/mL as no protection. For the analysis, we used SPSS version 11.5 software. A two-sided p-value less 0.05 was considered statistically significant. RESULTS: In patients with beta thalassemia major, antibody level against tetanus was inversely dependent about 29.3% to serum ferritin level. Thus, when serum ferritin increased 1 ng/mL, serum antibody against tetanus decreased 0.002 IU/mL. Mean anti-tetanus (IgG) antibody titers was lower in thalassemia patients compared to healthy subjects (1.53 ± 1.71 vs. 2.02 ± 2.05, p = 0.007) that was no significantly associated to age and gender in both study groups. All of participants had serum antibody level 0.01 IU/mL or greater. The complete protective level of anti-tetanus antibody was lower in thalassemia subjects in compare to healthy persons (71% vs. 87.9%, p < 0.001). CONCLUSION: Patients with thalassemia had lower anti-tetanus antibody level than healthy subjects. Thus the vaccine recommendation seems essential for patients with beta thalassemia major. The Korean Vaccine Society 2015-07 2015-07-29 /pmc/articles/PMC4524903/ /pubmed/26273577 http://dx.doi.org/10.7774/cevr.2015.4.2.184 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jahromi, Abdolreza Sotoodeh
Rahmanian, Karamatollah
Immunity to tetanus in major beta thalassemia patients
title Immunity to tetanus in major beta thalassemia patients
title_full Immunity to tetanus in major beta thalassemia patients
title_fullStr Immunity to tetanus in major beta thalassemia patients
title_full_unstemmed Immunity to tetanus in major beta thalassemia patients
title_short Immunity to tetanus in major beta thalassemia patients
title_sort immunity to tetanus in major beta thalassemia patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524903/
https://www.ncbi.nlm.nih.gov/pubmed/26273577
http://dx.doi.org/10.7774/cevr.2015.4.2.184
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