Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial

We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48–119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. Howeve...

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Detalles Bibliográficos
Autores principales: McLean, Huong Q., Belongia, Edward A., Kieke, Burney A., Meece, Jennifer K., Fry, Alicia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525010/
https://www.ncbi.nlm.nih.gov/pubmed/26258157
http://dx.doi.org/10.1093/ofid/ofv100
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author McLean, Huong Q.
Belongia, Edward A.
Kieke, Burney A.
Meece, Jennifer K.
Fry, Alicia M.
author_facet McLean, Huong Q.
Belongia, Edward A.
Kieke, Burney A.
Meece, Jennifer K.
Fry, Alicia M.
author_sort McLean, Huong Q.
collection PubMed
description We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48–119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. However, the power of this study was limited due to lower than expected enrollment.
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spelling pubmed-45250102015-08-07 Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial McLean, Huong Q. Belongia, Edward A. Kieke, Burney A. Meece, Jennifer K. Fry, Alicia M. Open Forum Infect Dis Brief Reports We conducted a double-blind, randomized trial of 134 outpatients with polymerase chain reaction-confirmed influenza to assess the effects of oseltamivir initiated 48–119 hours after illness onset. Oseltamivir treatment did not reduce illness duration, severity, or duration of virus detection. However, the power of this study was limited due to lower than expected enrollment. Oxford University Press 2015-07-08 /pmc/articles/PMC4525010/ /pubmed/26258157 http://dx.doi.org/10.1093/ofid/ofv100 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
McLean, Huong Q.
Belongia, Edward A.
Kieke, Burney A.
Meece, Jennifer K.
Fry, Alicia M.
Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title_full Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title_fullStr Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title_full_unstemmed Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title_short Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
title_sort impact of late oseltamivir treatment on influenza symptoms in the outpatient setting: results of a randomized trial
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525010/
https://www.ncbi.nlm.nih.gov/pubmed/26258157
http://dx.doi.org/10.1093/ofid/ofv100
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