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miRegulome: a knowledge-base of miRNA regulomics and analysis
miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The fo...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525332/ https://www.ncbi.nlm.nih.gov/pubmed/26243198 http://dx.doi.org/10.1038/srep12832 |
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author | Barh, Debmalya Kamapantula, Bhanu Jain, Neha Nalluri, Joseph Bhattacharya, Antaripa Juneja, Lucky Barve, Neha Tiwari, Sandeep Miyoshi, Anderson Azevedo, Vasco Blum, Kenneth Kumar, Anil Silva, Artur Ghosh, Preetam |
author_facet | Barh, Debmalya Kamapantula, Bhanu Jain, Neha Nalluri, Joseph Bhattacharya, Antaripa Juneja, Lucky Barve, Neha Tiwari, Sandeep Miyoshi, Anderson Azevedo, Vasco Blum, Kenneth Kumar, Anil Silva, Artur Ghosh, Preetam |
author_sort | Barh, Debmalya |
collection | PubMed |
description | miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community. Availability: http://bnet.egr.vcu.edu/miRegulome. |
format | Online Article Text |
id | pubmed-4525332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45253322015-08-06 miRegulome: a knowledge-base of miRNA regulomics and analysis Barh, Debmalya Kamapantula, Bhanu Jain, Neha Nalluri, Joseph Bhattacharya, Antaripa Juneja, Lucky Barve, Neha Tiwari, Sandeep Miyoshi, Anderson Azevedo, Vasco Blum, Kenneth Kumar, Anil Silva, Artur Ghosh, Preetam Sci Rep Article miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide information on specific aspects of miRNA regulation. However, an integrated resource on the miRNA regulome is currently not available to facilitate the exploration and understanding of miRNA regulomics. miRegulome attempts to bridge this gap. The current version of miRegulome v1.0 provides details on the entire regulatory modules of miRNAs altered in response to chemical treatments and transcription factors, based on validated data manually curated from published literature. Modules of miRegulome (upstream regulators, downstream targets, miRNA regulated pathways, functions, diseases, etc) are hyperlinked to an appropriate external resource and are displayed visually to provide a comprehensive understanding. Four analysis tools are incorporated to identify relationships among different modules based on user specified datasets. miRegulome and its tools are helpful in understanding the biology of miRNAs and will also facilitate the discovery of biomarkers and therapeutics. With added features in upcoming releases, miRegulome will be an essential resource to the scientific community. Availability: http://bnet.egr.vcu.edu/miRegulome. Nature Publishing Group 2015-08-05 /pmc/articles/PMC4525332/ /pubmed/26243198 http://dx.doi.org/10.1038/srep12832 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Barh, Debmalya Kamapantula, Bhanu Jain, Neha Nalluri, Joseph Bhattacharya, Antaripa Juneja, Lucky Barve, Neha Tiwari, Sandeep Miyoshi, Anderson Azevedo, Vasco Blum, Kenneth Kumar, Anil Silva, Artur Ghosh, Preetam miRegulome: a knowledge-base of miRNA regulomics and analysis |
title | miRegulome: a knowledge-base of miRNA regulomics and analysis |
title_full | miRegulome: a knowledge-base of miRNA regulomics and analysis |
title_fullStr | miRegulome: a knowledge-base of miRNA regulomics and analysis |
title_full_unstemmed | miRegulome: a knowledge-base of miRNA regulomics and analysis |
title_short | miRegulome: a knowledge-base of miRNA regulomics and analysis |
title_sort | miregulome: a knowledge-base of mirna regulomics and analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525332/ https://www.ncbi.nlm.nih.gov/pubmed/26243198 http://dx.doi.org/10.1038/srep12832 |
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