Cargando…

Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis

Vascular endothelial dysfunction (VED) is an important factor in the initiation and development of atherosclerosis (AS). Previous studies have demonstrated that endothelial permeability is increased in diet-induced AS. However, the precise underlying mechanisms remain poorly understood. The present...

Descripción completa

Detalles Bibliográficos
Autores principales:	CHENG, XIAOWEN, WANG, XIAOBIAN, WAN, YUFENG, ZHOU, QING, ZHU, HUAQING, WANG, YUAN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526030/ https://www.ncbi.nlm.nih.gov/pubmed/26096176 http://dx.doi.org/10.3892/mmr.2015.3973

Ejemplares similares

Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits
por: CHENG, XIAOWEN, et al.
Publicado: (2015)

Phosphorylated-myosin light chain mediates the destruction of small intestinal epithelial tight junctions in mice with acute liver failure
por: Wu, Fan, et al.
Publicado: (2021)

Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells
por: Cong, Yizi, et al.
Publicado: (2020)

Cytotoxic Effects on HL-60 Cells of Myosin Light Chain Kinase Inhibitor ML-7 Alone and in Combination with Flavonoids
por: Lee, Joong Won, et al.
Publicado: (2009)

Preventive Effects of Thinned Apple Extracts on TNF-α-Induced Intestinal Tight Junction Dysfunction in Caco-2 Cells through Myosin Light Chain Kinase Suppression
por: Lee, Joo-Yeon, et al.
Publicado: (2022)

Enterohemorrhagic Escherichia coli Effector Protein EspF Interacts With Host Protein ANXA6 and Triggers Myosin Light Chain Kinase (MLCK)-Dependent Tight Junction Dysregulation
por: Hua, Ying, et al.
Publicado: (2020)

Protein Kinase Cβ Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor–Induced Permeability In Vivo
por: Murakami, Tomoaki, et al.
Publicado: (2012)

Abl Tyrosine Kinase Phosphorylates Nonmuscle Myosin Light Chain Kinase to Regulate Endothelial Barrier Function
por: Dudek, Steven M., et al.
Publicado: (2010)

AMP-activated protein kinase preserves endothelial tight junctions in the coronary microcirculation during sepsis
por: Castanares-Zapatero, D, et al.
Publicado: (2012)

Endothelial tight junctions form the blood–brain barrier
por: Bonetta, Laura
Publicado: (2005)

All-trans-Retinoic Acid Ameliorated High Fat Diet-Induced Atherosclerosis in Rabbits by Inhibiting Platelet Activation and Inflammation
por: Zhou, Birong, et al.
Publicado: (2012)

Noncanonical function of long myosin light chain kinase in increasing ER‐PM junctions and augmentation of SOCE
por: Srivastava, Nityanand, et al.
Publicado: (2020)

Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation
Publicado: (1995)

Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and function
Publicado: (1987)

KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke
por: Zhang, Xinyu, et al.
Publicado: (2020)

Melatonin Potentiates Sensitivity to 5-Fluorouracil in Gastric Cancer Cells by Upregulating Autophagy and Downregulating Myosin Light-Chain Kinase
por: Shi, Xiaorui, et al.
Publicado: (2023)

Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells
por: Holzner, Silvio, et al.
Publicado: (2021)

Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells
por: Luo, Yang, et al.
Publicado: (2023)

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction
por: Pan, Pan, et al.
Publicado: (2021)

Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis
por: Takahashi, Lisa, et al.
Publicado: (2021)

MicroRNA-126 Modulates Palmitate-Induced Migration in HUVECs by Downregulating Myosin Light Chain Kinase via the ERK/MAPK Pathway
por: Wang, Yi, et al.
Publicado: (2020)

Endothelial Claudin: Claudin-5/Tmvcf Constitutes Tight Junction Strands in Endothelial Cells
por: Morita, Kazumasa, et al.
Publicado: (1999)

Myosin V: tight grip and big steps
por: Wells, William A.
Publicado: (2001)

Airway tight junctions as targets of viral infections: Tight Junctions and Viral Infections
por: Linfield, Debra T., et al.
Publicado: (2021)

Myosins in cell junctions
por: Liu, Katy C., et al.
Publicado: (2012)

Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin
por: Dörfel, Max Johannes, et al.
Publicado: (2012)

Nonmuscle Myosin Light Chain Kinase: A Key Player in Intermittent Hypoxia‐Induced Vascular Alterations
por: Arnaud, Claire, et al.
Publicado: (2018)

A role for myosin IXb, a motor–RhoGAP chimera, in epithelial wound healing and tight junction regulation
por: Chandhoke, Surjit K., et al.
Publicado: (2012)

Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development
Publicado: (1996)

Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin
por: Hitsumoto, Tatsuro, et al.
Publicado: (2023)

Tight junction between endothelial cells: the interaction between nanoparticles and blood vessels
por: Zhang, Yue, et al.
Publicado: (2016)

Sticking it out with tight junctions
por: Powell, Kendall
Publicado: (2005)

Tight junctions loosen up
por: Leslie, Mitch
Publicado: (2008)

The molecular organization of tight junctions
Publicado: (1993)

Tight Junctions in Salivary Epithelium
por: Baker, Olga J.
Publicado: (2010)

The kidney tight junction (Review)
por: HOU, JIANGHUI
Publicado: (2014)

Tight Junctions Go Viral!
por: Torres-Flores, Jesús M., et al.
Publicado: (2015)

Tight Junctions and the Tumor Microenvironment
por: Salvador, Ellaine, et al.
Publicado: (2016)

Stinging Tight Junctions With WASPs
por: Aroeti, Benjamin, et al.
Publicado: (2018)

Tight Junctions in Cell Proliferation
por: Díaz-Coránguez, Mónica, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_592rmq3po0l866rt1mhscg3p7g