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Epigenetic alterations in gastric cancer (Review)
Gastric cancer is one of the most common types of cancer and the second most common cause of cancer-related mortality worldwide. An increasing number of recent studies have confirmed that gastric cancer is a multistage pathological state that arises from environmental factors; dietary factors in par...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526033/ https://www.ncbi.nlm.nih.gov/pubmed/25997695 http://dx.doi.org/10.3892/mmr.2015.3816 |
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author | FU, DU-GUAN |
author_facet | FU, DU-GUAN |
author_sort | FU, DU-GUAN |
collection | PubMed |
description | Gastric cancer is one of the most common types of cancer and the second most common cause of cancer-related mortality worldwide. An increasing number of recent studies have confirmed that gastric cancer is a multistage pathological state that arises from environmental factors; dietary factors in particulary are considered to play an important role in the etiology of gastric cancer. Improper dietary habits are one of the primary concerns as they influence key molecular events associated with the onset of gastric carcinogenesis. In the field of genetics, anticancer research has mainly focused on the various genetic markers and genetic molecular mechanisms responsible for the development of this of this disease. Some of this research has proven to be very fruitful, providing insight into the possible mechamisms repsonsible for this disease and into possible treatment modalities. However, the mortality rate associated with gastric cancer remains relatively high. Thus, epigenetics has become a hot topic for research, whereby genetic markers are bypassed and this research is directed towards reversible epigenetic events, such as methylation and histone modifications that play a crucial role in carcinogenesis. The present review focuses on the epigenetic events which play an important role in the development and progression of this deadly disease, gastric cancer. |
format | Online Article Text |
id | pubmed-4526033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-45260332015-11-30 Epigenetic alterations in gastric cancer (Review) FU, DU-GUAN Mol Med Rep Articles Gastric cancer is one of the most common types of cancer and the second most common cause of cancer-related mortality worldwide. An increasing number of recent studies have confirmed that gastric cancer is a multistage pathological state that arises from environmental factors; dietary factors in particulary are considered to play an important role in the etiology of gastric cancer. Improper dietary habits are one of the primary concerns as they influence key molecular events associated with the onset of gastric carcinogenesis. In the field of genetics, anticancer research has mainly focused on the various genetic markers and genetic molecular mechanisms responsible for the development of this of this disease. Some of this research has proven to be very fruitful, providing insight into the possible mechamisms repsonsible for this disease and into possible treatment modalities. However, the mortality rate associated with gastric cancer remains relatively high. Thus, epigenetics has become a hot topic for research, whereby genetic markers are bypassed and this research is directed towards reversible epigenetic events, such as methylation and histone modifications that play a crucial role in carcinogenesis. The present review focuses on the epigenetic events which play an important role in the development and progression of this deadly disease, gastric cancer. D.A. Spandidos 2015-09 2015-05-22 /pmc/articles/PMC4526033/ /pubmed/25997695 http://dx.doi.org/10.3892/mmr.2015.3816 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles FU, DU-GUAN Epigenetic alterations in gastric cancer (Review) |
title | Epigenetic alterations in gastric cancer (Review) |
title_full | Epigenetic alterations in gastric cancer (Review) |
title_fullStr | Epigenetic alterations in gastric cancer (Review) |
title_full_unstemmed | Epigenetic alterations in gastric cancer (Review) |
title_short | Epigenetic alterations in gastric cancer (Review) |
title_sort | epigenetic alterations in gastric cancer (review) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526033/ https://www.ncbi.nlm.nih.gov/pubmed/25997695 http://dx.doi.org/10.3892/mmr.2015.3816 |
work_keys_str_mv | AT fuduguan epigeneticalterationsingastriccancerreview |