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Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma

DLC1 has been shown to be downregulated or absent in hepatocellular carcinoma (HCC) and is associated with tumorigenesis and development. However, only a small number of studies have focused on genetic variations of DLC1. The present study performed exon sequencing for the DLC1 gene in HCC tissue sa...

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Autores principales: XIE, CHENG-RONG, SUN, HONG-GUANG, SUN, YU, ZHAO, WEN-XIU, ZHANG, SHENG, WANG, XIAO-MIN, YIN, ZHEN-YU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526053/
https://www.ncbi.nlm.nih.gov/pubmed/26095787
http://dx.doi.org/10.3892/mmr.2015.3970
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author XIE, CHENG-RONG
SUN, HONG-GUANG
SUN, YU
ZHAO, WEN-XIU
ZHANG, SHENG
WANG, XIAO-MIN
YIN, ZHEN-YU
author_facet XIE, CHENG-RONG
SUN, HONG-GUANG
SUN, YU
ZHAO, WEN-XIU
ZHANG, SHENG
WANG, XIAO-MIN
YIN, ZHEN-YU
author_sort XIE, CHENG-RONG
collection PubMed
description DLC1 has been shown to be downregulated or absent in hepatocellular carcinoma (HCC) and is associated with tumorigenesis and development. However, only a small number of studies have focused on genetic variations of DLC1. The present study performed exon sequencing for the DLC1 gene in HCC tissue samples from 105 patients to identify functional genetic variation of DLC1 and its association with HCC susceptibility, clinicopathological features and prognosis. A novel missense mutation and four non-synonymous single nucleotide polymorphisms (SNPs; rs3816748, rs11203495, rs3816747 and rs532841) were identified. A significant correlation of rs3816747 polymorphisms with HCC susceptibility was identified. Compared to individuals with the GG genotype of rs3816747, those with the GA (odds ratio (OR)=0.486; P=0.037) or GA+AA genotype (OR=0.51; P=0.039) were associated with a significantly decreased HCC risk. Furthermore, patients with the GC+CC genotype of rs3816748, the TC+CC genotype of rs11203495 or the GA+AA genotype of rs3816747 had small-sized tumors compared with those carrying the wild-type genotype. No significant association of DLC1 SNPs with the patients' prognosis was found. These results indicated that genetic variations in the DLC1 gene may confer a risk for HCC.
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spelling pubmed-45260532015-11-30 Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma XIE, CHENG-RONG SUN, HONG-GUANG SUN, YU ZHAO, WEN-XIU ZHANG, SHENG WANG, XIAO-MIN YIN, ZHEN-YU Mol Med Rep Articles DLC1 has been shown to be downregulated or absent in hepatocellular carcinoma (HCC) and is associated with tumorigenesis and development. However, only a small number of studies have focused on genetic variations of DLC1. The present study performed exon sequencing for the DLC1 gene in HCC tissue samples from 105 patients to identify functional genetic variation of DLC1 and its association with HCC susceptibility, clinicopathological features and prognosis. A novel missense mutation and four non-synonymous single nucleotide polymorphisms (SNPs; rs3816748, rs11203495, rs3816747 and rs532841) were identified. A significant correlation of rs3816747 polymorphisms with HCC susceptibility was identified. Compared to individuals with the GG genotype of rs3816747, those with the GA (odds ratio (OR)=0.486; P=0.037) or GA+AA genotype (OR=0.51; P=0.039) were associated with a significantly decreased HCC risk. Furthermore, patients with the GC+CC genotype of rs3816748, the TC+CC genotype of rs11203495 or the GA+AA genotype of rs3816747 had small-sized tumors compared with those carrying the wild-type genotype. No significant association of DLC1 SNPs with the patients' prognosis was found. These results indicated that genetic variations in the DLC1 gene may confer a risk for HCC. D.A. Spandidos 2015-09 2015-06-22 /pmc/articles/PMC4526053/ /pubmed/26095787 http://dx.doi.org/10.3892/mmr.2015.3970 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
XIE, CHENG-RONG
SUN, HONG-GUANG
SUN, YU
ZHAO, WEN-XIU
ZHANG, SHENG
WANG, XIAO-MIN
YIN, ZHEN-YU
Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title_full Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title_fullStr Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title_full_unstemmed Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title_short Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma
title_sort significance of genetic variants in dlc1 and their association with hepatocellular carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526053/
https://www.ncbi.nlm.nih.gov/pubmed/26095787
http://dx.doi.org/10.3892/mmr.2015.3970
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