GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration

Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insu...

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Autores principales: ZHOU, QIANG, ZHANG, JUNXIA, CUI, QINYING, LI, XIAODONG, GAO, GE, WANG, YANFEN, XU, YUPING, GAO, XIAOQUN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526077/
https://www.ncbi.nlm.nih.gov/pubmed/26035416
http://dx.doi.org/10.3892/mmr.2015.3869
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author ZHOU, QIANG
ZHANG, JUNXIA
CUI, QINYING
LI, XIAODONG
GAO, GE
WANG, YANFEN
XU, YUPING
GAO, XIAOQUN
author_facet ZHOU, QIANG
ZHANG, JUNXIA
CUI, QINYING
LI, XIAODONG
GAO, GE
WANG, YANFEN
XU, YUPING
GAO, XIAOQUN
author_sort ZHOU, QIANG
collection PubMed
description Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling pathway regulates cell proliferation, motility and survival. The dysregulation of this signaling pathway has been implicated in the development of malignant gliomas. In the present study, GSK1904529A, a small molecule inhibitor of IGF-1R, suppressed glioma cell viability, induced glioma cell apoptosis and inhibited glioma cell migration in vitro. In addition, GSK1904529A inhibited glioma tumor growth and induced tumor cell apoptosis in vivo. In conclusion, the results of the present study suggested GSK1904529A as a promising agent for the treatment of malignant glioma.
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spelling pubmed-45260772015-11-30 GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration ZHOU, QIANG ZHANG, JUNXIA CUI, QINYING LI, XIAODONG GAO, GE WANG, YANFEN XU, YUPING GAO, XIAOQUN Mol Med Rep Articles Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling pathway regulates cell proliferation, motility and survival. The dysregulation of this signaling pathway has been implicated in the development of malignant gliomas. In the present study, GSK1904529A, a small molecule inhibitor of IGF-1R, suppressed glioma cell viability, induced glioma cell apoptosis and inhibited glioma cell migration in vitro. In addition, GSK1904529A inhibited glioma tumor growth and induced tumor cell apoptosis in vivo. In conclusion, the results of the present study suggested GSK1904529A as a promising agent for the treatment of malignant glioma. D.A. Spandidos 2015-09 2015-05-28 /pmc/articles/PMC4526077/ /pubmed/26035416 http://dx.doi.org/10.3892/mmr.2015.3869 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
ZHOU, QIANG
ZHANG, JUNXIA
CUI, QINYING
LI, XIAODONG
GAO, GE
WANG, YANFEN
XU, YUPING
GAO, XIAOQUN
GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title_full GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title_fullStr GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title_full_unstemmed GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title_short GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
title_sort gsk1904529a, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526077/
https://www.ncbi.nlm.nih.gov/pubmed/26035416
http://dx.doi.org/10.3892/mmr.2015.3869
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