Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for embryonic angiogenesis in mice and interacts physically with CCM2, but how this interaction is mediated and its relevance to cerebral vasculature are...

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Detalles Bibliográficos
Autores principales: Fisher, Oriana S., Deng, Hanqiang, Liu, Dou, Zhang, Ya, Wei, Rong, Deng, Yong, Zhang, Fan, Louvi, Angeliki, Turk, Benjamin E., Boggon, Titus J., Su, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526114/
https://www.ncbi.nlm.nih.gov/pubmed/26235885
http://dx.doi.org/10.1038/ncomms8937

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