Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in...

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Detalles Bibliográficos
Autores principales: He, Shanshan, Zhao, Zhen, Yang, Yongfei, O'Connell, Douglas, Zhang, Xiaowei, Oh, Soohwan, Ma, Binyun, Lee, Joo-Hyung, Zhang, Tian, Varghese, Bino, Yip, Janae, Dolatshahi Pirooz, Sara, Li, Ming, Zhang, Yong, Li, Guo-Min, Ellen Martin, Sue, Machida, Keigo, Liang, Chengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526116/
https://www.ncbi.nlm.nih.gov/pubmed/26234763
http://dx.doi.org/10.1038/ncomms8839

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