Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial

BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis. DGAT1 plays a key role in the repackaging of dietary TG into circulating TG rich chylomicrons. A growing amount of research has indicated tha...

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Detalles Bibliográficos
Autores principales: Velliquette, Rodney A., Grann, Kerry, Missler, Stephen R., Patterson, Jennifer, Hu, Chun, Gellenbeck, Kevin W., Scholten, Jeffrey D., Randolph, R. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526202/
https://www.ncbi.nlm.nih.gov/pubmed/26246845
http://dx.doi.org/10.1186/s12986-015-0025-2

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