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Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have dem...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526216/ https://www.ncbi.nlm.nih.gov/pubmed/26266053 http://dx.doi.org/10.1155/2015/265967 |
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author | Rinaldi, Barbara Guida, Francesca Furiano, Anna Donniacuo, Maria Luongo, Livio Gritti, Giulia Urbanek, Konrad Messina, Giovanni Maione, Sabatino Rossi, Francesco de Novellis, Vito |
author_facet | Rinaldi, Barbara Guida, Francesca Furiano, Anna Donniacuo, Maria Luongo, Livio Gritti, Giulia Urbanek, Konrad Messina, Giovanni Maione, Sabatino Rossi, Francesco de Novellis, Vito |
author_sort | Rinaldi, Barbara |
collection | PubMed |
description | Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise. |
format | Online Article Text |
id | pubmed-4526216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45262162015-08-11 Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction Rinaldi, Barbara Guida, Francesca Furiano, Anna Donniacuo, Maria Luongo, Livio Gritti, Giulia Urbanek, Konrad Messina, Giovanni Maione, Sabatino Rossi, Francesco de Novellis, Vito Neural Plast Research Article Myocardial infarction (MI) is one of the leading causes of death in developed countries and it is characterized by several associated symptomatologies and poor quality of life. Recent data showed a possible interaction between infarction and brain inflammation and activity. Previous studies have demonstrated the beneficial effect of exercise training on deterioration in cardiac function after MI. In this study we analyzed in sedentary and trained rats the microglia and astrocytes 48 hours after MI in PVN, thalamus, prefrontal cortex, and hippocampus through immunofluorescence approach. We found significant changes in specific microglia phenotypes in the brain areas analyzed together with astrocytes activation. Prolonged exercise normalized these morphological changes of microglia and astrocytes in the prefrontal cortex, hippocampus, and thalamus but not in the PVN. Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise. Hindawi Publishing Corporation 2015 2015-07-22 /pmc/articles/PMC4526216/ /pubmed/26266053 http://dx.doi.org/10.1155/2015/265967 Text en Copyright © 2015 Barbara Rinaldi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rinaldi, Barbara Guida, Francesca Furiano, Anna Donniacuo, Maria Luongo, Livio Gritti, Giulia Urbanek, Konrad Messina, Giovanni Maione, Sabatino Rossi, Francesco de Novellis, Vito Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title_full | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title_fullStr | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title_full_unstemmed | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title_short | Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction |
title_sort | effect of prolonged moderate exercise on the changes of nonneuronal cells in early myocardial infarction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526216/ https://www.ncbi.nlm.nih.gov/pubmed/26266053 http://dx.doi.org/10.1155/2015/265967 |
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