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May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients
BACKGROUND: Vitamin D deficiency has been associated with a high number of health outcomes, and its role on the immune system has been deeply investigated in recent years, although poor data are still available on vitamin D status in orthopedic infections including those of prosthetic implants. METH...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526280/ https://www.ncbi.nlm.nih.gov/pubmed/26242985 http://dx.doi.org/10.1186/s12891-015-0648-5 |
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author | Signori, Valentina Romanò, Carlo L. De Vecchi, Elena Mattina, Roberto Drago, Lorenzo |
author_facet | Signori, Valentina Romanò, Carlo L. De Vecchi, Elena Mattina, Roberto Drago, Lorenzo |
author_sort | Signori, Valentina |
collection | PubMed |
description | BACKGROUND: Vitamin D deficiency has been associated with a high number of health outcomes, and its role on the immune system has been deeply investigated in recent years, although poor data are still available on vitamin D status in orthopedic infections including those of prosthetic implants. METHODS: We focused on preoperative values of 25(OH)D in selected groups of patients with septic (Group A) or aseptic (Group B) prosthetic loosening, infective bone disease such as septic arthritis and osteomyelitis (Group C) and other orthopedic pathologies (Group D) to evaluate differences in the vitamin D status. RESULTS: A high prevalence of vitamin D deficiency was recorded among the study population (16.5 ± 5.4 ng/mL, mean ± SD). Interestingly, all patients with an infection presented a higher 25(OH)D concentration (17.7 ± 5.3 ng/mL) in respect to uninfected ones (15.1 ± 5.6 ng/mL). Significantly higher levels of 25(OH)D were observed in patients with prosthetic joint infection (18.5 ± 6.5 ng/mL), when compared with those presenting an aseptic loosening (13.6 ± 9.4 ng/mL). CONCLUSIONS: Deficiency in vitamin D levels have been found in orthopaedic patients. Prosthetic joint infections seems to be associated to higher values of vitamin D in respect to other bone infections or to other orthopaedic conditions requiring surgery. More studies are needed to improve the knowledge on vitamin D status in these patients and to better clarify the role of vitamin D in relation to osteoarticular infections. |
format | Online Article Text |
id | pubmed-4526280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45262802015-08-06 May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients Signori, Valentina Romanò, Carlo L. De Vecchi, Elena Mattina, Roberto Drago, Lorenzo BMC Musculoskelet Disord Research Article BACKGROUND: Vitamin D deficiency has been associated with a high number of health outcomes, and its role on the immune system has been deeply investigated in recent years, although poor data are still available on vitamin D status in orthopedic infections including those of prosthetic implants. METHODS: We focused on preoperative values of 25(OH)D in selected groups of patients with septic (Group A) or aseptic (Group B) prosthetic loosening, infective bone disease such as septic arthritis and osteomyelitis (Group C) and other orthopedic pathologies (Group D) to evaluate differences in the vitamin D status. RESULTS: A high prevalence of vitamin D deficiency was recorded among the study population (16.5 ± 5.4 ng/mL, mean ± SD). Interestingly, all patients with an infection presented a higher 25(OH)D concentration (17.7 ± 5.3 ng/mL) in respect to uninfected ones (15.1 ± 5.6 ng/mL). Significantly higher levels of 25(OH)D were observed in patients with prosthetic joint infection (18.5 ± 6.5 ng/mL), when compared with those presenting an aseptic loosening (13.6 ± 9.4 ng/mL). CONCLUSIONS: Deficiency in vitamin D levels have been found in orthopaedic patients. Prosthetic joint infections seems to be associated to higher values of vitamin D in respect to other bone infections or to other orthopaedic conditions requiring surgery. More studies are needed to improve the knowledge on vitamin D status in these patients and to better clarify the role of vitamin D in relation to osteoarticular infections. BioMed Central 2015-08-05 /pmc/articles/PMC4526280/ /pubmed/26242985 http://dx.doi.org/10.1186/s12891-015-0648-5 Text en © Signori et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Signori, Valentina Romanò, Carlo L. De Vecchi, Elena Mattina, Roberto Drago, Lorenzo May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title | May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title_full | May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title_fullStr | May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title_full_unstemmed | May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title_short | May osteoarticular infections be influenced by vitamin D status? An observational study on selected patients |
title_sort | may osteoarticular infections be influenced by vitamin d status? an observational study on selected patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526280/ https://www.ncbi.nlm.nih.gov/pubmed/26242985 http://dx.doi.org/10.1186/s12891-015-0648-5 |
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