Cargando…
Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation
Little is known about how patients undergoing stem cell transplantation (HCT) and their family caregivers (FC) perceive their prognosis. We examined prognostic understanding in patients undergoing HCT and their FC and its relationship with quality of life (QOL) and mood. We conducted a longitudinal...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526323/ https://www.ncbi.nlm.nih.gov/pubmed/25961772 http://dx.doi.org/10.1038/bmt.2015.113 |
_version_ | 1782384406567059456 |
---|---|
author | El-Jawahri, Areej Traeger, Lara Kuzmuk, Kailyn Eusebio, Justin Vandusen, Harry Keenan, Tanya Shin, Jennifer Gallagher, Emily R. Greer, Joseph A. Pirl, William F. Jackson, Vicki A. Ballen, Karen K Spitzer, Thomas R. Graubert, Timothy A. McAfee, Steven Dey, Bimalangshu Chen, Yi-Bin A. Temel, Jennifer S. |
author_facet | El-Jawahri, Areej Traeger, Lara Kuzmuk, Kailyn Eusebio, Justin Vandusen, Harry Keenan, Tanya Shin, Jennifer Gallagher, Emily R. Greer, Joseph A. Pirl, William F. Jackson, Vicki A. Ballen, Karen K Spitzer, Thomas R. Graubert, Timothy A. McAfee, Steven Dey, Bimalangshu Chen, Yi-Bin A. Temel, Jennifer S. |
author_sort | El-Jawahri, Areej |
collection | PubMed |
description | Little is known about how patients undergoing stem cell transplantation (HCT) and their family caregivers (FC) perceive their prognosis. We examined prognostic understanding in patients undergoing HCT and their FC and its relationship with quality of life (QOL) and mood. We conducted a longitudinal study of patients (and FC) hospitalized for HCT. We used a questionnaire to measure participants’ prognostic understanding and asked the oncologists to estimate patients’ prognosis prior to HCT. We assessed QOL and mood weekly and evaluated the relationship between prognostic understanding and QOL and mood using multivariable linear mixed models. We enrolled 90 patients undergoing (autologous n=30); myeloablative (n=30) or reduced intensity allogeneic (n=30)) HCT. 88.9% of patients and 87.1% of FC reported it is ‘extremely’ or ‘very’ important to know about prognosis. However, 77.6% of patients and 71.7% of FC reported a discordance and more optimistic prognostic perception compared to the oncologist (P’s < 0.0001). Patients with a concordant prognostic understanding with their oncologists reported worse QOL (β = −9.4, P = 0.01) and greater depression at baseline (β = 1.7, P = 0.02) and over time ((β = 1.2, P < 0.0001). Therefore, Interventions are needed to improve prognostic understanding, while providing patients with adequate psychological support. |
format | Online Article Text |
id | pubmed-4526323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45263232016-01-31 Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation El-Jawahri, Areej Traeger, Lara Kuzmuk, Kailyn Eusebio, Justin Vandusen, Harry Keenan, Tanya Shin, Jennifer Gallagher, Emily R. Greer, Joseph A. Pirl, William F. Jackson, Vicki A. Ballen, Karen K Spitzer, Thomas R. Graubert, Timothy A. McAfee, Steven Dey, Bimalangshu Chen, Yi-Bin A. Temel, Jennifer S. Bone Marrow Transplant Article Little is known about how patients undergoing stem cell transplantation (HCT) and their family caregivers (FC) perceive their prognosis. We examined prognostic understanding in patients undergoing HCT and their FC and its relationship with quality of life (QOL) and mood. We conducted a longitudinal study of patients (and FC) hospitalized for HCT. We used a questionnaire to measure participants’ prognostic understanding and asked the oncologists to estimate patients’ prognosis prior to HCT. We assessed QOL and mood weekly and evaluated the relationship between prognostic understanding and QOL and mood using multivariable linear mixed models. We enrolled 90 patients undergoing (autologous n=30); myeloablative (n=30) or reduced intensity allogeneic (n=30)) HCT. 88.9% of patients and 87.1% of FC reported it is ‘extremely’ or ‘very’ important to know about prognosis. However, 77.6% of patients and 71.7% of FC reported a discordance and more optimistic prognostic perception compared to the oncologist (P’s < 0.0001). Patients with a concordant prognostic understanding with their oncologists reported worse QOL (β = −9.4, P = 0.01) and greater depression at baseline (β = 1.7, P = 0.02) and over time ((β = 1.2, P < 0.0001). Therefore, Interventions are needed to improve prognostic understanding, while providing patients with adequate psychological support. 2015-05-11 2015-08 /pmc/articles/PMC4526323/ /pubmed/25961772 http://dx.doi.org/10.1038/bmt.2015.113 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article El-Jawahri, Areej Traeger, Lara Kuzmuk, Kailyn Eusebio, Justin Vandusen, Harry Keenan, Tanya Shin, Jennifer Gallagher, Emily R. Greer, Joseph A. Pirl, William F. Jackson, Vicki A. Ballen, Karen K Spitzer, Thomas R. Graubert, Timothy A. McAfee, Steven Dey, Bimalangshu Chen, Yi-Bin A. Temel, Jennifer S. Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title | Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title_full | Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title_fullStr | Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title_full_unstemmed | Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title_short | Prognostic Understanding, Quality of Life, and Mood in Patients Undergoing Hematopoietic Stem Cell Transplantation |
title_sort | prognostic understanding, quality of life, and mood in patients undergoing hematopoietic stem cell transplantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526323/ https://www.ncbi.nlm.nih.gov/pubmed/25961772 http://dx.doi.org/10.1038/bmt.2015.113 |
work_keys_str_mv | AT eljawahriareej prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT traegerlara prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT kuzmukkailyn prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT eusebiojustin prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT vandusenharry prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT keenantanya prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT shinjennifer prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT gallagheremilyr prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT greerjosepha prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT pirlwilliamf prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT jacksonvickia prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT ballenkarenk prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT spitzerthomasr prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT grauberttimothya prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT mcafeesteven prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT deybimalangshu prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT chenyibina prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation AT temeljennifers prognosticunderstandingqualityoflifeandmoodinpatientsundergoinghematopoieticstemcelltransplantation |