An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses. In the absence of helper viruses, host factors such as the proteasome and DNA damage response machinery have been shown to effectivel...

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Detalles Bibliográficos
Autores principales: Schreiber, Claire A., Sakuma, Toshie, Izumiya, Yoshihiro, Holditch, Sara J., Hickey, Raymond D., Bressin, Robert K., Basu, Upamanyu, Koide, Kazunori, Asokan, Aravind, Ikeda, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526370/
https://www.ncbi.nlm.nih.gov/pubmed/26244496
http://dx.doi.org/10.1371/journal.ppat.1005082

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