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Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain

Histone deacetylases (HDAC’s) became increasingly important targets for therapy of various diseases, resulting in a pressing need to develop HDAC class- and isoform-selective inhibitors. Class IIa deacetylases possess only minimal deacetylase activity against acetylated histones, but have several ot...

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Detalles Bibliográficos
Autores principales:	Bonomi, Robin, Mukhopadhyay, Uday, Shavrin, Aleksandr, Yeh, Hsien-Hsien, Majhi, Anjoy, Dewage, Sajeewa W., Najjar, Amer, Lu, Xin, Cisneros, G. Andrés, Tong, William P., Alauddin, Mian M., Liu, Ren-Shuan, Mangner, Thomas J., Turkman, Nashaat, Gelovani, Juri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526562/ https://www.ncbi.nlm.nih.gov/pubmed/26244761 http://dx.doi.org/10.1371/journal.pone.0133512

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