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Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects

ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity, and their quantitative relationship in 11,67...

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Autores principales: Song, Jaewoo, Chen, Fengju, Campos, Marco, Bolgiano, Doug, Houck, Katie, Chambless, Lloyd E., Wu, Kenneth K., Folsom, Aaron R., Couper, David, Boerwinkle, Eric, Dong, Jing-fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526567/
https://www.ncbi.nlm.nih.gov/pubmed/26244499
http://dx.doi.org/10.1371/journal.pone.0132626
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author Song, Jaewoo
Chen, Fengju
Campos, Marco
Bolgiano, Doug
Houck, Katie
Chambless, Lloyd E.
Wu, Kenneth K.
Folsom, Aaron R.
Couper, David
Boerwinkle, Eric
Dong, Jing-fei
author_facet Song, Jaewoo
Chen, Fengju
Campos, Marco
Bolgiano, Doug
Houck, Katie
Chambless, Lloyd E.
Wu, Kenneth K.
Folsom, Aaron R.
Couper, David
Boerwinkle, Eric
Dong, Jing-fei
author_sort Song, Jaewoo
collection PubMed
description ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity, and their quantitative relationship in 11,673 participants in the Atherosclerosis Risk in Communities (ARIC) study. VWF, FVIII, and FVIII/VWF levels varied significantly among O, A (A1 and A2), B and AB subjects, and the extent of which varied between Americans of European (EA) and African (AA) descent. We validated a strong influence of ABO blood type on VWF levels (15.2%), but also detected a direct ABO influence on FVIII activity (0.6%) and FVIII/VWF ratio (3.8%) after adjustment for VWF. We determined that FVIII activity changed 0.54% for every 1% change in VWF antigen level. This VWF-FVIII relationship differed between subjects with O and B blood types in EA, AA, and in male, but not female subjects. Variations in FVIII activity were primarily detected at low VWF levels. These new quantitative influences on VWF, FVIII and the FVIII/VWF ratio help understand how ABO genotypes differentially influence VWF, FVIII and their ratio, particularly in racial and gender specific manners.
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spelling pubmed-45265672015-08-12 Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects Song, Jaewoo Chen, Fengju Campos, Marco Bolgiano, Doug Houck, Katie Chambless, Lloyd E. Wu, Kenneth K. Folsom, Aaron R. Couper, David Boerwinkle, Eric Dong, Jing-fei PLoS One Research Article ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity, and their quantitative relationship in 11,673 participants in the Atherosclerosis Risk in Communities (ARIC) study. VWF, FVIII, and FVIII/VWF levels varied significantly among O, A (A1 and A2), B and AB subjects, and the extent of which varied between Americans of European (EA) and African (AA) descent. We validated a strong influence of ABO blood type on VWF levels (15.2%), but also detected a direct ABO influence on FVIII activity (0.6%) and FVIII/VWF ratio (3.8%) after adjustment for VWF. We determined that FVIII activity changed 0.54% for every 1% change in VWF antigen level. This VWF-FVIII relationship differed between subjects with O and B blood types in EA, AA, and in male, but not female subjects. Variations in FVIII activity were primarily detected at low VWF levels. These new quantitative influences on VWF, FVIII and the FVIII/VWF ratio help understand how ABO genotypes differentially influence VWF, FVIII and their ratio, particularly in racial and gender specific manners. Public Library of Science 2015-08-05 /pmc/articles/PMC4526567/ /pubmed/26244499 http://dx.doi.org/10.1371/journal.pone.0132626 Text en © 2015 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Song, Jaewoo
Chen, Fengju
Campos, Marco
Bolgiano, Doug
Houck, Katie
Chambless, Lloyd E.
Wu, Kenneth K.
Folsom, Aaron R.
Couper, David
Boerwinkle, Eric
Dong, Jing-fei
Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title_full Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title_fullStr Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title_full_unstemmed Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title_short Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects
title_sort quantitative influence of abo blood groups on factor viii and its ratio to von willebrand factor, novel observations from an aric study of 11,673 subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526567/
https://www.ncbi.nlm.nih.gov/pubmed/26244499
http://dx.doi.org/10.1371/journal.pone.0132626
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