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Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC–MS/MS

PURPOSE: Polyesters with hydrophilic domains, i.e., poly(d,l-lactic-co-glycolic-co-hydroxymethyl glycolic acid) (PLGHMGA) and a multiblock copolymer of poly(ε-caprolactone)-PEG-poly(ε-caprolactone) and poly(l-lactide) ((PC-PEG-PC)-(PL)) are expected to cause less acylation of encapsulated peptides t...

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Detalles Bibliográficos
Autores principales:	Shirangi, Mehrnoosh, Hennink, Wim E., Somsen, Govert W., van Nostrum, Cornelus F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526596/ https://www.ncbi.nlm.nih.gov/pubmed/25832500 http://dx.doi.org/10.1007/s11095-015-1685-3

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