Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L(−)C7L(−) Mutant

RNA interference (RNAi) screens intended to identify host factors that restrict virus replication may fail if the virus already counteracts host defense mechanisms. To overcome this limitation, we are investigating the use of viral host range mutants that exhibit impaired replication in nonpermissiv...

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Detalles Bibliográficos
Autores principales: Sivan, Gilad, Ormanoglu, Pinar, Buehler, Eugen C., Martin, Scott E., Moss, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526713/
https://www.ncbi.nlm.nih.gov/pubmed/26242627
http://dx.doi.org/10.1128/mBio.01122-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526713/
https://www.ncbi.nlm.nih.gov/pubmed/26242627
http://dx.doi.org/10.1128/mBio.01122-15

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