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The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most aggressive human solid malignancies known. NMC is driven by the creation of a translocation oncoprotein, BRD4-NUT, which blocks differentiation and drives growth of NMC cells. BRD4-NUT forms distinctive nuclear foci i...

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Detalles Bibliográficos
Autores principales:	Alekseyenko, Artyom A., Walsh, Erica M., Wang, Xin, Grayson, Adlai R., Hsi, Peter T., Kharchenko, Peter V., Kuroda, Mitzi I., French, Christopher A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526735/ https://www.ncbi.nlm.nih.gov/pubmed/26220994 http://dx.doi.org/10.1101/gad.267583.115

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