Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this region is bound by ribosomal proteins, particularly ribosomal protein L11 (RPL11), leading to MDM2 inactivation and subsequent p53 activation. Here, we solved the complex structure of human M...

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Detalles Bibliográficos
Autores principales: Zheng, Jiangge, Lang, Yue, Zhang, Qi, Cui, Di, Sun, Haili, Jiang, Lun, Chen, Zhenhang, Zhang, Rui, Gao, Yina, Tian, Wenli, Wu, Wei, Tang, Jun, Chen, Zhongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526736/
https://www.ncbi.nlm.nih.gov/pubmed/26220995
http://dx.doi.org/10.1101/gad.261792.115

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