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Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost invariably fatal malignancy. Although conventional genetically engineered mouse models of human PDAC have been instrumental in understanding pancreatic cancer development, these models are much too labor-intensiv...

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Detalles Bibliográficos
Autores principales:	Chiou, Shin-Heng, Winters, Ian P., Wang, Jing, Naranjo, Santiago, Dudgeon, Crissy, Tamburini, Fiona B., Brady, Jennifer J., Yang, Dian, Grüner, Barbara M., Chuang, Chen-Hua, Caswell, Deborah R., Zeng, Hong, Chu, Pauline, Kim, Grace E., Carpizo, Darren R., Kim, Seung K., Winslow, Monte M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Resource/Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526740/ https://www.ncbi.nlm.nih.gov/pubmed/26178787 http://dx.doi.org/10.1101/gad.264861.115

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