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Peripheral blood cells from children with RASopathies show enhanced spontaneous colonies growth in vitro and hyperactive RAS signaling
Germline mutations in genes coding for molecules involved in the RAS/RAF/MEK/ERK pathway are the hallmarks of a newly classified family of autosomal dominant syndromes termed RASopathies. Myeloproliferative disorders (MPDs), in particular, juvenile myelomonocytic leukemia, can lead to potentially se...
Autores principales: | Gaipa, G, Bugarin, C, Cianci, P, Sarno, J, Bonaccorso, P, Biondi, A, Selicorni, A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526778/ https://www.ncbi.nlm.nih.gov/pubmed/26186557 http://dx.doi.org/10.1038/bcj.2015.52 |
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