TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution

The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this mutation during the clinical course remains unclear. In this study, TP53 mutations were identified in 7% of 500 patients with de novo AML and 58.8% of patients wit...

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Detalles Bibliográficos
Autores principales: Hou, H-A, Chou, W-C, Kuo, Y-Y, Liu, C-Y, Lin, L-I, Tseng, M-H, Chiang, Y-C, Liu, M-C, Liu, C-W, Tang, J-L, Yao, M, Li, C-C, Huang, S-Y, Ko, B-S, Hsu, S-C, Chen, C-Y, Lin, C-T, Wu, S-J, Tsay, W, Chen, Y-C, Tien, H-F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526785/
https://www.ncbi.nlm.nih.gov/pubmed/26230955
http://dx.doi.org/10.1038/bcj.2015.59

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