Cargando…

mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity

There is evidence that an inflammatory microenvironment is associated with the development and progression of prostate cancer (PCa), although the determinants of intrinsic inflammation in PCa cells are not completely understood. Here we investigated whether expression of intrinsic microsomal PGE syn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Finetti, Federica, Terzuoli, Erika, Giachetti, Antonio, Santi, Raffaella, Villari, Donata, Hanaka, Hiromi, Radmark, Olof, Ziche, Marina, Donnini, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526795/ https://www.ncbi.nlm.nih.gov/pubmed/26113609 http://dx.doi.org/10.1530/ERC-15-0277

Ejemplares similares

Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and −186 expression: Novel mechanism of VEGF modulation in prostate cancer
por: Terzuoli, Erika, et al.
Publicado: (2016)

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis
por: Finetti, Federica, et al.
Publicado: (2012)

Targeting mPGES-1 as a New Strategy against Neuroblastoma
por: Comunanza, Valentina
Publicado: (2018)

Analgesic effects of a highly selective mPGES-1 inhibitor
por: Stewart, Madeline J., et al.
Publicado: (2023)

Inhibition of cell cycle progression by the hydroxytyrosol–cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells
por: Terzuoli, Erika, et al.
Publicado: (2017)

Involvement of Bradykinin B2 Receptor in Pathological Vascularization in Oxygen-Induced Retinopathy in Mice and Rabbit Cornea
por: Terzuoli, Erika, et al.
Publicado: (2018)

Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells
por: Ciccone, Valerio, et al.
Publicado: (2018)

Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells
por: Ciccone, Valerio, et al.
Publicado: (2019)

Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1
por: Terzuoli, Erika, et al.
Publicado: (2018)

Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
por: Takeda, H, et al.
Publicado: (2004)

Transcriptional regulation of the mPGES-1 gene in primary cultured articular chondrocytes
por: Bausero, P, et al.
Publicado: (2004)

mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
por: Kirkby, Nicholas S, et al.
Publicado: (2019)

Monitoring Endothelial and Tissue Responses to Cobalt Ferrite Nanoparticles and Hybrid Hydrogels
por: Finetti, Federica, et al.
Publicado: (2016)

Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
por: Radi, Zaher A., et al.
Publicado: (2007)

Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis
por: McCann, Matthew R, et al.
Publicado: (2011)

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice
por: Brenneis, Christian, et al.
Publicado: (2008)

Arzanol, a Potent mPGES-1 Inhibitor: Novel Anti-Inflammatory Agent
por: Kothavade, Pankaj S., et al.
Publicado: (2013)

ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output
por: Terzuoli, Erika, et al.
Publicado: (2019)

The role of mPGES-1 for prostaglandin E(2 )production in primary human synovial cells
por: Crofford, L, et al.
Publicado: (2003)

mPGES-1 and prostaglandin E(2): vital role in inflammation, hypoxic response, and survival
por: Siljehav, Veronica, et al.
Publicado: (2012)

Role of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury
por: Jia, Zhanjun, et al.
Publicado: (2015)

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
por: Noha, Stefan M., et al.
Publicado: (2015)

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
por: de Oliveira, Antonio Carlos Pinheiro, et al.
Publicado: (2016)

The Augmenting Effects of Desolvation and Conformational Energy Terms on the Predictions of Docking Programs against mPGES-1
por: Gupta, Ashish, et al.
Publicado: (2015)

CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors
por: Chen, Zhanfei, et al.
Publicado: (2019)

ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties
por: Nannelli, G., et al.
Publicado: (2018)

Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human Endothelial Cells by Quenching the NF-kB Pathway Activation
por: Terzuoli, Erika, et al.
Publicado: (2014)

Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene
por: Gosset, Marjolaine, et al.
Publicado: (2006)

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
por: de Oliveira, Antonio CP, et al.
Publicado: (2012)

Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2017)

DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1
por: Zhou, Shuo, et al.
Publicado: (2020)

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
por: Di Micco, Simone, et al.
Publicado: (2021)

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome
por: Luo, Qimei, et al.
Publicado: (2021)

Mycobacterium tuberculosis-Induced Upregulation of the COX-2/mPGES-1 Pathway in Human Macrophages Is Abrogated by Sulfasalazine
por: Wang, Wenfei, et al.
Publicado: (2022)

PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice
por: Sun, Ying, et al.
Publicado: (2013)

Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE(2) Cascade
por: Wang, Haiping, et al.
Publicado: (2015)

mPGES-1-Mediated Production of PGE(2) and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation
por: Maseda, Damian, et al.
Publicado: (2018)

Effect of Proton Pump Inhibitor Therapy on NOX5, mPGES1 and iNOS expression in Barrett’s Esophagus
por: Li, Dan, et al.
Publicado: (2019)

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression
por: Rappl, Peter, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i0tonrvr3r121patmmpk16qtgo