Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia

Sjögren syndrome (SS) is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Fluorodeoxyglucose position emission tomography/computed...

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Autores principales: Ahmed, Fatma, Raslan, Osama, Muzaffar, Razi, Parkar, Nadeem, Marwaha, Nitin, Osman, Medhat M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526815/
https://www.ncbi.nlm.nih.gov/pubmed/26301203
http://dx.doi.org/10.3389/fonc.2015.00179
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author Ahmed, Fatma
Raslan, Osama
Muzaffar, Razi
Parkar, Nadeem
Marwaha, Nitin
Osman, Medhat M.
author_facet Ahmed, Fatma
Raslan, Osama
Muzaffar, Razi
Parkar, Nadeem
Marwaha, Nitin
Osman, Medhat M.
author_sort Ahmed, Fatma
collection PubMed
description Sjögren syndrome (SS) is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Fluorodeoxyglucose position emission tomography/computed tomography (F-18 FDG PET/CT) for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be mucosa-associated lymphoid tissue lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia.
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spelling pubmed-45268152015-08-21 Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia Ahmed, Fatma Raslan, Osama Muzaffar, Razi Parkar, Nadeem Marwaha, Nitin Osman, Medhat M. Front Oncol Oncology Sjögren syndrome (SS) is an autoimmune disease with exocrine glands dysfunction and multiorgan involvement. It is associated with increased risk of lymphoproliferative disorders, especially B-cell marginal zone lymphoma. While the role of F-18 Fluorodeoxyglucose position emission tomography/computed tomography (F-18 FDG PET/CT) for evaluation of lymphoma has been established, its use in patients with a chronic history of SS to evaluate for possible lymphoproliferative disorders or multiorgan involvement is limited. We present a case of chronic SS in which F-18 FDG PET/CT demonstrated FDG avid intraparotid and cervical lymph nodes pathologically proven to be mucosa-associated lymphoid tissue lymphoma. In addition, the patient had bibasilar cystic changes consistent with lymphocytic interstitial pneumonia. Frontiers Media S.A. 2015-08-06 /pmc/articles/PMC4526815/ /pubmed/26301203 http://dx.doi.org/10.3389/fonc.2015.00179 Text en Copyright © 2015 Ahmed, Raslan, Muzaffar, Parkar, Marwaha and Osman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ahmed, Fatma
Raslan, Osama
Muzaffar, Razi
Parkar, Nadeem
Marwaha, Nitin
Osman, Medhat M.
Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title_full Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title_fullStr Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title_full_unstemmed Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title_short Sjögren Syndrome Complicated by Mucosa-Associated Lymphoid Tissue Lymphoma and Lymphocytic Interstitial Pneumonia
title_sort sjögren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526815/
https://www.ncbi.nlm.nih.gov/pubmed/26301203
http://dx.doi.org/10.3389/fonc.2015.00179
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