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Neuroprotective potential of Beta vulgaris L. in Parkinson's disease

OBJECTIVE: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson's disease (PD). MATERIALS AND METHODS: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experi...

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Autores principales: Nade, Vandana S., Kawale, Laxman A., Zambre, Shankar S., Kapure, Amit B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527062/
https://www.ncbi.nlm.nih.gov/pubmed/26288473
http://dx.doi.org/10.4103/0253-7613.161263
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author Nade, Vandana S.
Kawale, Laxman A.
Zambre, Shankar S.
Kapure, Amit B.
author_facet Nade, Vandana S.
Kawale, Laxman A.
Zambre, Shankar S.
Kapure, Amit B.
author_sort Nade, Vandana S.
collection PubMed
description OBJECTIVE: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson's disease (PD). MATERIALS AND METHODS: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experimental animals. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. Foot shock-induced aggression (FSIA) model was used to confirm anti-parkinsonian activity. The methanolic extract of Beta vulgaris (MEBV) was administered at doses of 100, 200, and 300 mg/kg, p.o. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in FSIA model in rat brain. RESULTS: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by MEBV. In FSIA, the biochemical analysis of brain revealed the increased level of lipid peroxidation (LPO) and decreased levels of superoxide dismutase (SOD) and catalase (CAT). MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain. CONCLUSIONS: The results indicated the protective role of B. vulgaris against PD. The mechanism of protection may be due to augmentation of cellular antioxidants.
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spelling pubmed-45270622015-08-18 Neuroprotective potential of Beta vulgaris L. in Parkinson's disease Nade, Vandana S. Kawale, Laxman A. Zambre, Shankar S. Kapure, Amit B. Indian J Pharmacol Research Article OBJECTIVE: The objective was to investigate the neuroprotective role of Beta vulgaris in Parkinson's disease (PD). MATERIALS AND METHODS: PD was induced by administration of reserpine (5 mg/kg/day, i.p for 5 consecutive days), haloperidol (1 mg/kg, i.p.), and tacrine (2.5 mg/kg, i.p.) in experimental animals. The symptoms of PD such as tremors, akinesia, rigidity, catalepsy, and vacuous chewing movements (VCMs) were evaluated. Foot shock-induced aggression (FSIA) model was used to confirm anti-parkinsonian activity. The methanolic extract of Beta vulgaris (MEBV) was administered at doses of 100, 200, and 300 mg/kg, p.o. The combination of L-dopa and carbidopa was used as a standard drug. Behavioral studies such as locomotor activity and grip strength were determined, and oxidative stress was evaluated in FSIA model in rat brain. RESULTS: Pretreatment with MEBV (200 and 300 mg/kg) significantly reduced the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, VCMs, and increase fighting behavior. The locomotor activity and grip strength were significantly increased by MEBV. In FSIA, the biochemical analysis of brain revealed the increased level of lipid peroxidation (LPO) and decreased levels of superoxide dismutase (SOD) and catalase (CAT). MEBV significantly reduced LPO level and restored the defensive antioxidant enzymes SOD and CAT in rat brain. CONCLUSIONS: The results indicated the protective role of B. vulgaris against PD. The mechanism of protection may be due to augmentation of cellular antioxidants. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4527062/ /pubmed/26288473 http://dx.doi.org/10.4103/0253-7613.161263 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nade, Vandana S.
Kawale, Laxman A.
Zambre, Shankar S.
Kapure, Amit B.
Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title_full Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title_fullStr Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title_full_unstemmed Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title_short Neuroprotective potential of Beta vulgaris L. in Parkinson's disease
title_sort neuroprotective potential of beta vulgaris l. in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527062/
https://www.ncbi.nlm.nih.gov/pubmed/26288473
http://dx.doi.org/10.4103/0253-7613.161263
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