Cargando…
Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements
Dysfunctional adipose tissue represents a hallmark of type 2 diabetes and systemic insulin resistance, characterized by fibrotic deposition of collagens and increased immune cell infiltration within the depots. Here we generate an inducible model of loss of function of the protein phosphatase and te...
Autores principales: | Morley, Thomas S., Xia, Jonathan Y., Scherer, Philipp E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527086/ https://www.ncbi.nlm.nih.gov/pubmed/26243466 http://dx.doi.org/10.1038/ncomms8906 |
Ejemplares similares
-
Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice
por: Hepler, Chelsea, et al.
Publicado: (2017) -
The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes
por: Chaudhuri, Rima, et al.
Publicado: (2018) -
Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism
por: Macotela, Yazmin, et al.
Publicado: (2009) -
Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes
por: Dipta, Priya, et al.
Publicado: (2021) -
Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice
por: Bruckbauer, Antje, et al.
Publicado: (2012)