Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

BACKGROUND: Controlled human malaria infection (CHMI) by mosquito bite is a powerful tool for evaluation of vaccines and drugs against Plasmodium falciparum malaria. However, only a small number of research centres have the facilities required to perform such studies. CHMI by needle and syringe coul...

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Detalles Bibliográficos
Autores principales: Gómez-Pérez, Gloria P, Legarda, Almudena, Muñoz, Jose, Sim, B Kim Lee, Ballester, María Rosa, Dobaño, Carlota, Moncunill, Gemma, Campo, Joseph J, Cisteró, Pau, Jimenez, Alfons, Barrios, Diana, Mordmüller, Benjamin, Pardos, Josefina, Navarro, Mireia, Zita, Cecilia Justino, Nhamuave, Carlos Arlindo, García-Basteiro, Alberto L, Sanz, Ariadna, Aldea, Marta, Manoj, Anita, Gunasekera, Anusha, Billingsley, Peter F, Aponte, John J, James, Eric R, Guinovart, Caterina, Antonijoan, Rosa M, Kremsner, Peter G, Hoffman, Stephen L, Alonso, Pedro L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527105/
https://www.ncbi.nlm.nih.gov/pubmed/26245196
http://dx.doi.org/10.1186/s12936-015-0817-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527105/
https://www.ncbi.nlm.nih.gov/pubmed/26245196
http://dx.doi.org/10.1186/s12936-015-0817-x

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