IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren’s syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22

INTRODUCTION: IL-17 has a putative role in the pathophysiology of Sjogren’s syndrome (SS) and has been shown to be upregulated in the salivary glands of affected individuals. Sequestration of IL-17 with Adenoviral-mediated gene therapy has previously shown a benefit upon the SS-like phenotype in the...

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Detalles Bibliográficos
Autores principales: Wu, Changgong, Wang, Zhimin, Zourelias, Lee, Thakker, Hiteshi, Passineau, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527205/
https://www.ncbi.nlm.nih.gov/pubmed/26245278
http://dx.doi.org/10.1186/s13075-015-0714-2

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