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S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation
BACKGROUND: Periodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527225/ https://www.ncbi.nlm.nih.gov/pubmed/26251029 http://dx.doi.org/10.1186/s12903-015-0077-8 |
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author | Kuzenko, Yevhen Romanyuk, Anatoliy Politun, Antonina Karpenko, Ludmila |
author_facet | Kuzenko, Yevhen Romanyuk, Anatoliy Politun, Antonina Karpenko, Ludmila |
author_sort | Kuzenko, Yevhen |
collection | PubMed |
description | BACKGROUND: Periodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase expression in periodontal inflammation. METHODS: 27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and hematoxylin - eosin. RESULTS: Giant-cells in epulis positivity for myeloperoxidase has been observed in 100 % However, only 75.31 % of giant-cells were positive for bcl2 expression. Acute 98.2 %, and chronic 89.28 % inflammation was a significant positive for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have showed the result of 100 %, 82,2 %, 100 % positive cells in acute and 100 %, 78.25 %, 100 % in chronic process of inflammation respectively. CONCLUSION: The results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation. |
format | Online Article Text |
id | pubmed-4527225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45272252015-08-07 S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation Kuzenko, Yevhen Romanyuk, Anatoliy Politun, Antonina Karpenko, Ludmila BMC Oral Health Research Article BACKGROUND: Periodontal inflammation is characterized by injuries in collagen, epithelial, bone tissues. The hypotheses to be tested were relationship between the s100, bcl2 and myeloperoxidase in gingival tissues (MPO does affect the level of s100, bcl2). The object of this study was to investigate of s100 expression, bcl2 expression and myeloperoxidase expression in periodontal inflammation. METHODS: 27 patients (giant-cell epulis) and 30 patients (acute and chronic inflammations) were included in the study for s100 expression, bcl2 expression and myeloperoxidase expression by immunohistochemistry and hematoxylin - eosin. RESULTS: Giant-cells in epulis positivity for myeloperoxidase has been observed in 100 % However, only 75.31 % of giant-cells were positive for bcl2 expression. Acute 98.2 %, and chronic 89.28 % inflammation was a significant positive for myeloperoxidase. The immunohistochemical findings of s100, bcl 2 and myeloperoxidase in epithelial layers have showed the result of 100 %, 82,2 %, 100 % positive cells in acute and 100 %, 78.25 %, 100 % in chronic process of inflammation respectively. CONCLUSION: The results indicate that the pathogenesis of periodontal inflammation might involve inhibition of cell death, through the overexpression of bcl-2, due to identifying factors myeloperoxidase (result in the DNA damage by the product of catalysis). The highest levels of s100 activity have been found at sites with chronic inflammation. BioMed Central 2015-08-07 /pmc/articles/PMC4527225/ /pubmed/26251029 http://dx.doi.org/10.1186/s12903-015-0077-8 Text en © Kuzenko et al. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kuzenko, Yevhen Romanyuk, Anatoliy Politun, Antonina Karpenko, Ludmila S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title_full | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title_fullStr | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title_full_unstemmed | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title_short | S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
title_sort | s100, bcl2 and myeloperoxid protein expirations during periodontal inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527225/ https://www.ncbi.nlm.nih.gov/pubmed/26251029 http://dx.doi.org/10.1186/s12903-015-0077-8 |
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