Upregulated IL-1β in dysferlin-deficient muscle attenuates regeneration by blunting the response to pro-inflammatory macrophages

BACKGROUND: Loss-of-function mutations in the dysferlin gene (DYSF) result in a family of muscle disorders known collectively as the dysferlinopathies. Dysferlin-deficient muscle is characterized by inflammatory foci and macrophage infiltration with subsequent decline in muscle function. Whereas mac...

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Detalles Bibliográficos
Autores principales: Cohen, Tatiana V., Many, Gina M., Fleming, Bryan D., Gnocchi, Viola F., Ghimbovschi, Svetlana, Mosser, David M., Hoffman, Eric P., Partridge, Terence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527226/
https://www.ncbi.nlm.nih.gov/pubmed/26251696
http://dx.doi.org/10.1186/s13395-015-0048-4

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