RASopathies: unraveling mechanisms with animal models

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RASopathies are developmental disorders caused by germline mutations in the Ras-MAPK pathway, and are characterized by a broad spectrum of functional and morphological abnormalities. The high incidence of these disorders (∼1/1000 births) motivates the development of systematic approaches for their e...

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Detalles Bibliográficos
Autores principales: Jindal, Granton A., Goyal, Yogesh, Burdine, Rebecca D., Rauen, Katherine A., Shvartsman, Stanislav Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527292/
https://www.ncbi.nlm.nih.gov/pubmed/26203125
http://dx.doi.org/10.1242/dmm.020339
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