Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis

Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we perfo...

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Detalles Bibliográficos
Autores principales: Chew, Thean S., O'Shea, Nuala R., Sewell, Gavin W., Oehlers, Stefan H., Mulvey, Claire M., Crosier, Philip S., Godovac-Zimmermann, Jasminka, Bloom, Stuart L., Smith, Andrew M., Segal, Anthony W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527293/
https://www.ncbi.nlm.nih.gov/pubmed/26044960
http://dx.doi.org/10.1242/dmm.020362

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