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Systems biology from virus to humans
Natural infection and then recovery are considered to be the most effective means for hosts to build protective immunity. Thus, mimicking natural infection of pathogens, many live attenuated vaccines such as influenza virus, and yellow fever vaccine 17D were developed and have been successfully used...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korea Basic Science Institute
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527316/ https://www.ncbi.nlm.nih.gov/pubmed/26269748 http://dx.doi.org/10.1186/s40543-015-0047-4 |
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author | Lee, Youri Kim, Yu-Jin Jung, Yu-Jin Kim, Ki-Hye Kwon, Young-Man Kim, Seung Il Kang, Sang-Moo |
author_facet | Lee, Youri Kim, Yu-Jin Jung, Yu-Jin Kim, Ki-Hye Kwon, Young-Man Kim, Seung Il Kang, Sang-Moo |
author_sort | Lee, Youri |
collection | PubMed |
description | Natural infection and then recovery are considered to be the most effective means for hosts to build protective immunity. Thus, mimicking natural infection of pathogens, many live attenuated vaccines such as influenza virus, and yellow fever vaccine 17D were developed and have been successfully used to induce protective immunity. However, humans fail to generate long-term protective immunity to some pathogens after natural infection such as influenza virus, respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV) even if they survive initial infections. Many vaccines are suboptimal since much mortality is still occurring, which is exampled by influenza and tuberculosis. It is critically important to increase our understanding on protein components of pathogens and vaccines as well as cellular and host responses to infections and vaccinations. Here, we highlight recent advances in gene transcripts and protein analysis results in the systems biology to enhance our understanding of viral pathogens, vaccines, and host cell responses. |
format | Online Article Text |
id | pubmed-4527316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korea Basic Science Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-45273162015-08-10 Systems biology from virus to humans Lee, Youri Kim, Yu-Jin Jung, Yu-Jin Kim, Ki-Hye Kwon, Young-Man Kim, Seung Il Kang, Sang-Moo J Anal Sci Technol Review Natural infection and then recovery are considered to be the most effective means for hosts to build protective immunity. Thus, mimicking natural infection of pathogens, many live attenuated vaccines such as influenza virus, and yellow fever vaccine 17D were developed and have been successfully used to induce protective immunity. However, humans fail to generate long-term protective immunity to some pathogens after natural infection such as influenza virus, respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV) even if they survive initial infections. Many vaccines are suboptimal since much mortality is still occurring, which is exampled by influenza and tuberculosis. It is critically important to increase our understanding on protein components of pathogens and vaccines as well as cellular and host responses to infections and vaccinations. Here, we highlight recent advances in gene transcripts and protein analysis results in the systems biology to enhance our understanding of viral pathogens, vaccines, and host cell responses. Korea Basic Science Institute 2015-02-05 2015 /pmc/articles/PMC4527316/ /pubmed/26269748 http://dx.doi.org/10.1186/s40543-015-0047-4 Text en © Lee et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Review Lee, Youri Kim, Yu-Jin Jung, Yu-Jin Kim, Ki-Hye Kwon, Young-Man Kim, Seung Il Kang, Sang-Moo Systems biology from virus to humans |
title | Systems biology from virus to humans |
title_full | Systems biology from virus to humans |
title_fullStr | Systems biology from virus to humans |
title_full_unstemmed | Systems biology from virus to humans |
title_short | Systems biology from virus to humans |
title_sort | systems biology from virus to humans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527316/ https://www.ncbi.nlm.nih.gov/pubmed/26269748 http://dx.doi.org/10.1186/s40543-015-0047-4 |
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