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Deletion of angiotensin-converting enzyme 2 exacerbates renal inflammation and injury in apolipoprotein E-deficient mice through modulation of the nephrin and TNF-alpha-TNFRSF1A signaling

BACKGROUND: The renin-angiotensin system (RAS) has been implicated in atherosclerotic lesions and progression to chronic kidney diseases. We examined regulatory roles of angiotensin-converting enzyme 2 (ACE2) in the apolipoprotein E (ApoE) knockout (KO) kidneys. METHODS: The 3-month-old wild-type, A...

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Detalles Bibliográficos
Autores principales:	Jin, Hai-Yan, Chen, Lai-Jiang, Zhang, Zhen-Zhou, Xu, Ying-Le, Song, Bei, Xu, Ran, Oudit, Gavin Y, Gao, Ping-Jin, Zhu, Ding-Liang, Zhong, Jiu-Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527357/ https://www.ncbi.nlm.nih.gov/pubmed/26245758 http://dx.doi.org/10.1186/s12967-015-0616-8

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