Regulation of a strong F9 cryptic 5′ss by intrinsic elements and by combination of tailored U1snRNAs with antisense oligonucleotides

Mutations affecting specific splicing regulatory elements offer suitable models to better understand their interplay and to devise therapeutic strategies. Here we characterize a meaningful splicing model in which numerous Hemophilia B-causing mutations, either missense or at the donor splice site (5...

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Detalles Bibliográficos
Autores principales: Balestra, Dario, Barbon, Elena, Scalet, Daniela, Cavallari, Nicola, Perrone, Daniela, Zanibellato, Silvia, Bernardi, Francesco, Pinotti, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527485/
https://www.ncbi.nlm.nih.gov/pubmed/26063760
http://dx.doi.org/10.1093/hmg/ddv205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527485/
https://www.ncbi.nlm.nih.gov/pubmed/26063760
http://dx.doi.org/10.1093/hmg/ddv205

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