Cargando…

Nanoemulsions as novel oral carriers of stiripentol: insights into the protective effect and absorption enhancement

Oral administration remains a significant challenge in regards to drugs with serious solubility and stability issues. This article aimed to investigate the suitability of nanoemulsions as oral carriers of stiripentol (STP), an acid-labile drug, for enhancement of stability and bioavailability. STP-l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Rong, Liu, Shan, Wang, Qilin, Li, Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527565/ https://www.ncbi.nlm.nih.gov/pubmed/26261418 http://dx.doi.org/10.2147/IJN.S87471

Ejemplares similares

Stiripentol for Dravet syndrome
Publicado: (2020)

Antiepileptic Stiripentol May Influence Bones
por: Matuszewska, Agnieszka, et al.
Publicado: (2021)

Is stiripentol truly effective for treating primary hyperoxaluria?
por: Martin-Higueras, Cristina, et al.
Publicado: (2020)

Audit of use of stiripentol in adults with Dravet syndrome
por: Balestrini, S., et al.
Publicado: (2016)

Intranasal Microemulsion as an Innovative and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting
por: Meirinho, Sara, et al.
Publicado: (2023)

Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
por: Afifi, Samar
Publicado: (2015)

Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions
por: Sun, Deqing, et al.
Publicado: (2014)

Commentary: Targeting LDH enzymes with a stiripentol analog to treat epilepsy
por: Cho, Chang-Hoon
Publicado: (2015)

Efficacy of Stiripentol in Dravet Syndrome with or without SCN1A Mutations
por: Cho, Min Jung, et al.
Publicado: (2018)

Absorption and Bioavailability of Novel UltraShear Nanoemulsion of Cannabidiol in Rats
por: ElSohly, Mahmoud A., et al.
Publicado: (2023)

Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids
por: Subedi, Laxman, et al.
Publicado: (2022)

Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient
por: Kempf, Caroline, et al.
Publicado: (2020)

Cationic nanoemulsions as potential carriers for intracellular delivery
por: Khachane, P.V., et al.
Publicado: (2015)

Aminoclay–lipid hybrid composite as a novel drug carrier of fenofibrate for the enhancement of drug release and oral absorption
por: Yang, Liang, et al.
Publicado: (2016)

Development of a New Ex Vivo Lipolysis-Absorption Model for Nanoemulsions
por: Xiao, Lu, et al.
Publicado: (2019)

Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery
por: Wang, Chuanqi, et al.
Publicado: (2022)

Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine–phospholipid nanocomplex
por: Hu, Jiangbo, et al.
Publicado: (2014)

The Effect of Nanoemulsion as a Carrier of Hydrophilic Compound for Transdermal Delivery
por: Tsai, Ming-Jun, et al.
Publicado: (2014)

A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied
por: Ye, Jing-Yi, et al.
Publicado: (2020)

Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect
por: Pangeni, Rudra, et al.
Publicado: (2018)

Protective Effect of Quercetin Nanoemulsion on 5-Fluorouracil-Induced Oral Mucositis in Mice
por: Lotfi, Mandana, et al.
Publicado: (2021)

Nanostructured Lipid Carriers Can Enhance Oral Absorption of Khellin, a Natural Pleiotropic Molecule
por: Vanti, Giulia, et al.
Publicado: (2021)

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability
por: Anuar, Nurfazreen, et al.
Publicado: (2020)

EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers
por: Granja, Andreia, et al.
Publicado: (2019)

A novel 5-Fluorocuracil multiple-nanoemulsion used for the enhancement of oral bioavailability in the treatment of colorectal cancer
por: Ahmad, Niyaz, et al.
Publicado: (2022)

Enhancing the Oral Bioavailability of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers: In Vitro Characterization and Absorption in Rats after Oral Administration
por: Anwar, Walid, et al.
Publicado: (2020)

Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial
por: Nabbout, Rima, et al.
Publicado: (2020)

Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review
por: Meirinho, Sara, et al.
Publicado: (2021)

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels
por: Smoleński, Michał, et al.
Publicado: (2021)

Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine
por: Chen, Yan, et al.
Publicado: (2012)

Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer
por: Shen, Qi, et al.
Publicado: (2011)

Enhanced Intestinal Absorption of Insulin by Capryol 90, a Novel Absorption Enhancer in Rats: Implications in Oral Insulin Delivery
por: Ukai, Hiroki, et al.
Publicado: (2020)

Recent insights into Nanoemulsions: Their preparation, properties and applications
por: Mushtaq, Abeeda, et al.
Publicado: (2023)

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils
por: Zhou, Xinhui, et al.
Publicado: (2018)

Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and Characterization
por: Özdemir, Samet, et al.
Publicado: (2023)

Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives
por: Salvia-Trujillo, Laura, et al.
Publicado: (2016)

Emerging role of nanoemulsions in oral health management
por: Narang, Jasjeet Kaur, et al.
Publicado: (2017)

A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form
por: Darwish, Hany W., et al.
Publicado: (2014)

Efficacy and Safety of Long-Term Treatment with Stiripentol in Children and Adults with Drug-Resistant Epilepsies: A Retrospective Cohort Study of 196 Patients
por: Balestrini, Simona, et al.
Publicado: (2022)

Stiripentol inhibits spike‐and‐wave discharges in animal models of absence seizures: A new mechanism of action involving T‐type calcium channels
por: Riban, Veronique, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dhja3scc2qjn11ep51sli65qv3