Cargando…
A Pan-GTPase Inhibitor as a Molecular Probe
Overactive GTPases have often been linked to human diseases. The available inhibitors are limited and have not progressed far in clinical trials. We report here a first-in-class small molecule pan-GTPase inhibitor discovered from a high throughput screening campaign. The compound CID1067700 inhibits...
Autores principales: | Hong, Lin, Guo, Yuna, BasuRay, Soumik, Agola, Jacob O., Romero, Elsa, Simpson, Denise S., Schroeder, Chad E., Simons, Peter, Waller, Anna, Garcia, Matthew, Carter, Mark, Ursu, Oleg, Gouveia, Kristine, Golden, Jennifer E., Aubé, Jeffrey, Wandinger-Ness, Angela, Sklar, Larry A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527730/ https://www.ncbi.nlm.nih.gov/pubmed/26247207 http://dx.doi.org/10.1371/journal.pone.0134317 |
Ejemplares similares
-
Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities
por: Agola, JO, et al.
Publicado: (2011) -
Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases
por: Oprea, Tudor I., et al.
Publicado: (2015) -
Rab7 Mutants Associated with Charcot-Marie-Tooth Disease Exhibit Enhanced NGF-Stimulated Signaling
por: BasuRay, Soumik, et al.
Publicado: (2010) -
Activation of Rho Family GTPases by Small Molecules
por: Palsuledesai, Charuta C., et al.
Publicado: (2018) -
Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe
por: Hong, Lin, et al.
Publicado: (2013)