Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient

We report a case of TTP in a sickle cell/β+-thalassemia heterozygote with nonspecific complaints and a evidence of hemolysis, initially attributed to sickle crisis. Included in this case is a discussion of the development of functional hyposplenism, a rarely reported complication, limitation of ADAM...

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Detalles Bibliográficos
Autores principales: Gangemi, Andrew J, Pickens, Peter V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527787/
https://www.ncbi.nlm.nih.gov/pubmed/26273433
http://dx.doi.org/10.1002/ccr3.202
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author Gangemi, Andrew J
Pickens, Peter V
author_facet Gangemi, Andrew J
Pickens, Peter V
author_sort Gangemi, Andrew J
collection PubMed
description We report a case of TTP in a sickle cell/β+-thalassemia heterozygote with nonspecific complaints and a evidence of hemolysis, initially attributed to sickle crisis. Included in this case is a discussion of the development of functional hyposplenism, a rarely reported complication, limitation of ADAMTS-13 in diagnosis, and the use of platelet transfusion.
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spelling pubmed-45277872015-08-13 Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient Gangemi, Andrew J Pickens, Peter V Clin Case Rep Case Reports We report a case of TTP in a sickle cell/β+-thalassemia heterozygote with nonspecific complaints and a evidence of hemolysis, initially attributed to sickle crisis. Included in this case is a discussion of the development of functional hyposplenism, a rarely reported complication, limitation of ADAMTS-13 in diagnosis, and the use of platelet transfusion. John Wiley & Sons, Ltd 2015-07 2015-05-05 /pmc/articles/PMC4527787/ /pubmed/26273433 http://dx.doi.org/10.1002/ccr3.202 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Gangemi, Andrew J
Pickens, Peter V
Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title_full Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title_fullStr Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title_full_unstemmed Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title_short Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β(+)-thalassemia patient
title_sort coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a hgbs/β(+)-thalassemia patient
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527787/
https://www.ncbi.nlm.nih.gov/pubmed/26273433
http://dx.doi.org/10.1002/ccr3.202
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