Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma

Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B-cell lymphoma. Treatment of lymphoma with rituximab and chlor...

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Autores principales: Meenhuis, Annemarie, van Vliet, Rianne, Hudig, Francisca, Ypma, Paula F, Schipperus, Martin R, Hollestelle, Martine J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527802/
https://www.ncbi.nlm.nih.gov/pubmed/26273448
http://dx.doi.org/10.1002/ccr3.294
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author Meenhuis, Annemarie
van Vliet, Rianne
Hudig, Francisca
Ypma, Paula F
Schipperus, Martin R
Hollestelle, Martine J
author_facet Meenhuis, Annemarie
van Vliet, Rianne
Hudig, Francisca
Ypma, Paula F
Schipperus, Martin R
Hollestelle, Martine J
author_sort Meenhuis, Annemarie
collection PubMed
description Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B-cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder.
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spelling pubmed-45278022015-08-13 Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma Meenhuis, Annemarie van Vliet, Rianne Hudig, Francisca Ypma, Paula F Schipperus, Martin R Hollestelle, Martine J Clin Case Rep Case Reports Prolonged clotting times were observed in a patient with spontaneous hemorrhage. Analysis showed severe factor X deficiency due to clearance by a noninhibitory antibody. Lymphadenopathy identified on imaging led to diagnosis of marginal B-cell lymphoma. Treatment of lymphoma with rituximab and chlorambucil resulted in complete disappearance of the bleeding disorder. John Wiley & Sons, Ltd 2015-07 2015-05-25 /pmc/articles/PMC4527802/ /pubmed/26273448 http://dx.doi.org/10.1002/ccr3.294 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Meenhuis, Annemarie
van Vliet, Rianne
Hudig, Francisca
Ypma, Paula F
Schipperus, Martin R
Hollestelle, Martine J
Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title_full Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title_fullStr Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title_full_unstemmed Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title_short Successful treatment of a noninhibitory antibody-mediated acquired factor X deficiency in a patient with marginal-zone lymphoma
title_sort successful treatment of a noninhibitory antibody-mediated acquired factor x deficiency in a patient with marginal-zone lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527802/
https://www.ncbi.nlm.nih.gov/pubmed/26273448
http://dx.doi.org/10.1002/ccr3.294
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