Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report

We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturban...

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Detalles Bibliográficos
Autores principales: Annaloro, Claudio, Costa, Antonella, Fracchiolla, Nicola S, Mometto, Gabriella, Artuso, Silvia, Saporiti, Giorgia, Tagliaferri, Elena, Grifoni, Federica, Onida, Francesco, Cortelezzi, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527817/
https://www.ncbi.nlm.nih.gov/pubmed/26273463
http://dx.doi.org/10.1002/ccr3.308
Descripción
Sumario:We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity.

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