Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report

We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturban...

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Autores principales: Annaloro, Claudio, Costa, Antonella, Fracchiolla, Nicola S, Mometto, Gabriella, Artuso, Silvia, Saporiti, Giorgia, Tagliaferri, Elena, Grifoni, Federica, Onida, Francesco, Cortelezzi, Agostino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527817/
https://www.ncbi.nlm.nih.gov/pubmed/26273463
http://dx.doi.org/10.1002/ccr3.308
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author Annaloro, Claudio
Costa, Antonella
Fracchiolla, Nicola S
Mometto, Gabriella
Artuso, Silvia
Saporiti, Giorgia
Tagliaferri, Elena
Grifoni, Federica
Onida, Francesco
Cortelezzi, Agostino
author_facet Annaloro, Claudio
Costa, Antonella
Fracchiolla, Nicola S
Mometto, Gabriella
Artuso, Silvia
Saporiti, Giorgia
Tagliaferri, Elena
Grifoni, Federica
Onida, Francesco
Cortelezzi, Agostino
author_sort Annaloro, Claudio
collection PubMed
description We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity.
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spelling pubmed-45278172015-08-13 Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report Annaloro, Claudio Costa, Antonella Fracchiolla, Nicola S Mometto, Gabriella Artuso, Silvia Saporiti, Giorgia Tagliaferri, Elena Grifoni, Federica Onida, Francesco Cortelezzi, Agostino Clin Case Rep Case Reports We present a case of severe, irreversible neurotoxicity in a 55-year-old-patient with myelofibrosis undergoing hematopoietic stem cell transplantation following a reduced intensity conditioning including fludarabine. The patient developed progressive sensory-motor, visual and consciousness disturbances, eventually leading to death. MRI imaging pattern was unique and attributable to fludarabine neurotoxicity. John Wiley & Sons, Ltd 2015-07 2015-06-11 /pmc/articles/PMC4527817/ /pubmed/26273463 http://dx.doi.org/10.1002/ccr3.308 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Annaloro, Claudio
Costa, Antonella
Fracchiolla, Nicola S
Mometto, Gabriella
Artuso, Silvia
Saporiti, Giorgia
Tagliaferri, Elena
Grifoni, Federica
Onida, Francesco
Cortelezzi, Agostino
Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title_full Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title_fullStr Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title_full_unstemmed Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title_short Severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
title_sort severe fludarabine neurotoxicity after reduced intensity conditioning regimen to allogeneic hematopoietic stem cell transplantation: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527817/
https://www.ncbi.nlm.nih.gov/pubmed/26273463
http://dx.doi.org/10.1002/ccr3.308
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