The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses

Flexible filamentous plant viruses are responsible for more than half the viral crop damage in the world, but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed due to the virion’s extreme flexibility. We have used cryo–EM to generate an at...

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Detalles Bibliográficos
Autores principales: DiMaio, Frank, Chen, Chun-Chieh, Yu, Xiong, Frenz, Brandon, Hsu, Yau-Heiu, Lin, Na-Sheng, Egelman, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527879/
https://www.ncbi.nlm.nih.gov/pubmed/26167882
http://dx.doi.org/10.1038/nsmb.3054
Descripción
Sumario:Flexible filamentous plant viruses are responsible for more than half the viral crop damage in the world, but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed due to the virion’s extreme flexibility. We have used cryo–EM to generate an atomic model for bamboo mosaic virus revealing flexible N– and C–terminal extensions that allow deformation while still maintaining structural integrity.

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