The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses

Flexible filamentous plant viruses are responsible for more than half the viral crop damage in the world, but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed due to the virion’s extreme flexibility. We have used cryo–EM to generate an at...

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Detalles Bibliográficos
Autores principales: DiMaio, Frank, Chen, Chun-Chieh, Yu, Xiong, Frenz, Brandon, Hsu, Yau-Heiu, Lin, Na-Sheng, Egelman, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527879/
https://www.ncbi.nlm.nih.gov/pubmed/26167882
http://dx.doi.org/10.1038/nsmb.3054
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author DiMaio, Frank
Chen, Chun-Chieh
Yu, Xiong
Frenz, Brandon
Hsu, Yau-Heiu
Lin, Na-Sheng
Egelman, Edward H.
author_facet DiMaio, Frank
Chen, Chun-Chieh
Yu, Xiong
Frenz, Brandon
Hsu, Yau-Heiu
Lin, Na-Sheng
Egelman, Edward H.
author_sort DiMaio, Frank
collection PubMed
description Flexible filamentous plant viruses are responsible for more than half the viral crop damage in the world, but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed due to the virion’s extreme flexibility. We have used cryo–EM to generate an atomic model for bamboo mosaic virus revealing flexible N– and C–terminal extensions that allow deformation while still maintaining structural integrity.
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spelling pubmed-45278792016-01-31 The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses DiMaio, Frank Chen, Chun-Chieh Yu, Xiong Frenz, Brandon Hsu, Yau-Heiu Lin, Na-Sheng Egelman, Edward H. Nat Struct Mol Biol Article Flexible filamentous plant viruses are responsible for more than half the viral crop damage in the world, but are also potentially useful for biotechnology. Structural studies began more than 75 years ago but have failed due to the virion’s extreme flexibility. We have used cryo–EM to generate an atomic model for bamboo mosaic virus revealing flexible N– and C–terminal extensions that allow deformation while still maintaining structural integrity. 2015-07-13 2015-08 /pmc/articles/PMC4527879/ /pubmed/26167882 http://dx.doi.org/10.1038/nsmb.3054 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
DiMaio, Frank
Chen, Chun-Chieh
Yu, Xiong
Frenz, Brandon
Hsu, Yau-Heiu
Lin, Na-Sheng
Egelman, Edward H.
The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title_full The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title_fullStr The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title_full_unstemmed The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title_short The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses
title_sort molecular basis for flexibility in the flexible filamentous plant viruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527879/
https://www.ncbi.nlm.nih.gov/pubmed/26167882
http://dx.doi.org/10.1038/nsmb.3054
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