Cargando…
A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress
Caregivers of patients receiving allogeneic hematopoietic stem cell transplants (Allo-HSCT) serve a pivotal role in patient care but experience high stress, anxiety, and depression as a result. We theorized that a stress management adapted for Allo-HSCT caregivers would reduce distress compared to t...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527944/ https://www.ncbi.nlm.nih.gov/pubmed/25961767 http://dx.doi.org/10.1038/bmt.2015.104 |
_version_ | 1782384631759241216 |
---|---|
author | Laudenslager, Mark L. Simoneau, Teri L. Kilbourn, Kristin Natvig, Crystal Philips, Sam Spradley, Janet Benitez, Patrick McSweeney, Peter Mikulich-Gilbertson, Susan K. |
author_facet | Laudenslager, Mark L. Simoneau, Teri L. Kilbourn, Kristin Natvig, Crystal Philips, Sam Spradley, Janet Benitez, Patrick McSweeney, Peter Mikulich-Gilbertson, Susan K. |
author_sort | Laudenslager, Mark L. |
collection | PubMed |
description | Caregivers of patients receiving allogeneic hematopoietic stem cell transplants (Allo-HSCT) serve a pivotal role in patient care but experience high stress, anxiety, and depression as a result. We theorized that a stress management adapted for Allo-HSCT caregivers would reduce distress compared to treatment as usual (TAU). From 267 consecutive caregivers of Allo-HSCT patients approached, 148 (mean=53.5 years, 75.7% female) were randomized to either psychosocial intervention (n=74) or TAU (n=74). Eight 1-on-1 stress management sessions delivered across the 100 day post-transplant period focused on understanding stress, changing role(s) as caregiver, cognitive behavioral stress management, pacing respiration, and identifying social support. Primary outcomes included perceived stress (psychological) and salivary cortisol awakening response (CAR) (physiological). Randomized groups were not statistically different at baseline. Mixed models analysis of covariance (intent-to-treat) showed that intervention was associated with significantly lower caregiver stress 3 months post-transplant (Mean=20.0, CI(95)=17.9-22.0) compared to TAU (Mean=23.0, CI(95)=21.0-25.0) with an effect size (ES) of 0.39 (p=0.039). Secondary psychological outcomes, including depression and anxiety, were significantly reduced with ESs of 0.46 and 0.66 respectively. Caregiver CAR did not differ from non-caregiving controls at baseline and was unchanged by intervention. Despite significant caregiving burden, this psychosocial intervention significantly mitigated distress in Allo-HSCT caregivers. |
format | Online Article Text |
id | pubmed-4527944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-45279442016-01-31 A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress Laudenslager, Mark L. Simoneau, Teri L. Kilbourn, Kristin Natvig, Crystal Philips, Sam Spradley, Janet Benitez, Patrick McSweeney, Peter Mikulich-Gilbertson, Susan K. Bone Marrow Transplant Article Caregivers of patients receiving allogeneic hematopoietic stem cell transplants (Allo-HSCT) serve a pivotal role in patient care but experience high stress, anxiety, and depression as a result. We theorized that a stress management adapted for Allo-HSCT caregivers would reduce distress compared to treatment as usual (TAU). From 267 consecutive caregivers of Allo-HSCT patients approached, 148 (mean=53.5 years, 75.7% female) were randomized to either psychosocial intervention (n=74) or TAU (n=74). Eight 1-on-1 stress management sessions delivered across the 100 day post-transplant period focused on understanding stress, changing role(s) as caregiver, cognitive behavioral stress management, pacing respiration, and identifying social support. Primary outcomes included perceived stress (psychological) and salivary cortisol awakening response (CAR) (physiological). Randomized groups were not statistically different at baseline. Mixed models analysis of covariance (intent-to-treat) showed that intervention was associated with significantly lower caregiver stress 3 months post-transplant (Mean=20.0, CI(95)=17.9-22.0) compared to TAU (Mean=23.0, CI(95)=21.0-25.0) with an effect size (ES) of 0.39 (p=0.039). Secondary psychological outcomes, including depression and anxiety, were significantly reduced with ESs of 0.46 and 0.66 respectively. Caregiver CAR did not differ from non-caregiving controls at baseline and was unchanged by intervention. Despite significant caregiving burden, this psychosocial intervention significantly mitigated distress in Allo-HSCT caregivers. 2015-05-11 2015-08 /pmc/articles/PMC4527944/ /pubmed/25961767 http://dx.doi.org/10.1038/bmt.2015.104 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Laudenslager, Mark L. Simoneau, Teri L. Kilbourn, Kristin Natvig, Crystal Philips, Sam Spradley, Janet Benitez, Patrick McSweeney, Peter Mikulich-Gilbertson, Susan K. A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title | A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title_full | A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title_fullStr | A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title_full_unstemmed | A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title_short | A randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: Effects on distress |
title_sort | randomized control trial of a psychosocial intervention for caregivers of allogeneic hematopoietic stem cell transplant patients: effects on distress |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527944/ https://www.ncbi.nlm.nih.gov/pubmed/25961767 http://dx.doi.org/10.1038/bmt.2015.104 |
work_keys_str_mv | AT laudenslagermarkl arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT simoneauteril arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT kilbournkristin arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT natvigcrystal arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT philipssam arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT spradleyjanet arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT benitezpatrick arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT mcsweeneypeter arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT mikulichgilbertsonsusank arandomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT laudenslagermarkl randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT simoneauteril randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT kilbournkristin randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT natvigcrystal randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT philipssam randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT spradleyjanet randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT benitezpatrick randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT mcsweeneypeter randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress AT mikulichgilbertsonsusank randomizedcontroltrialofapsychosocialinterventionforcaregiversofallogeneichematopoieticstemcelltransplantpatientseffectsondistress |