Erythropoietin dampens injury-induced microglial motility

Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical t...

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Detalles Bibliográficos
Autores principales: Mitkovski, Miso, Dahm, Liane, Heinrich, Ralf, Monnheimer, Mathieu, Gerhart, Simone, Stegmüller, Judith, Hanisch, Uwe-Karsten, Nave, Klaus-Armin, Ehrenreich, Hannelore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527993/
https://www.ncbi.nlm.nih.gov/pubmed/25966953
http://dx.doi.org/10.1038/jcbfm.2015.100
Descripción
Sumario:Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.

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