Erythropoietin dampens injury-induced microglial motility

Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical t...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitkovski, Miso, Dahm, Liane, Heinrich, Ralf, Monnheimer, Mathieu, Gerhart, Simone, Stegmüller, Judith, Hanisch, Uwe-Karsten, Nave, Klaus-Armin, Ehrenreich, Hannelore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527993/
https://www.ncbi.nlm.nih.gov/pubmed/25966953
http://dx.doi.org/10.1038/jcbfm.2015.100
_version_ 1782384634453032960
author Mitkovski, Miso
Dahm, Liane
Heinrich, Ralf
Monnheimer, Mathieu
Gerhart, Simone
Stegmüller, Judith
Hanisch, Uwe-Karsten
Nave, Klaus-Armin
Ehrenreich, Hannelore
author_facet Mitkovski, Miso
Dahm, Liane
Heinrich, Ralf
Monnheimer, Mathieu
Gerhart, Simone
Stegmüller, Judith
Hanisch, Uwe-Karsten
Nave, Klaus-Armin
Ehrenreich, Hannelore
author_sort Mitkovski, Miso
collection PubMed
description Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.
format Online
Article
Text
id pubmed-4527993
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-45279932015-08-07 Erythropoietin dampens injury-induced microglial motility Mitkovski, Miso Dahm, Liane Heinrich, Ralf Monnheimer, Mathieu Gerhart, Simone Stegmüller, Judith Hanisch, Uwe-Karsten Nave, Klaus-Armin Ehrenreich, Hannelore J Cereb Blood Flow Metab Brief Communication Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility. Nature Publishing Group 2015-08 2015-05-13 /pmc/articles/PMC4527993/ /pubmed/25966953 http://dx.doi.org/10.1038/jcbfm.2015.100 Text en Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Brief Communication
Mitkovski, Miso
Dahm, Liane
Heinrich, Ralf
Monnheimer, Mathieu
Gerhart, Simone
Stegmüller, Judith
Hanisch, Uwe-Karsten
Nave, Klaus-Armin
Ehrenreich, Hannelore
Erythropoietin dampens injury-induced microglial motility
title Erythropoietin dampens injury-induced microglial motility
title_full Erythropoietin dampens injury-induced microglial motility
title_fullStr Erythropoietin dampens injury-induced microglial motility
title_full_unstemmed Erythropoietin dampens injury-induced microglial motility
title_short Erythropoietin dampens injury-induced microglial motility
title_sort erythropoietin dampens injury-induced microglial motility
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527993/
https://www.ncbi.nlm.nih.gov/pubmed/25966953
http://dx.doi.org/10.1038/jcbfm.2015.100
work_keys_str_mv AT mitkovskimiso erythropoietindampensinjuryinducedmicroglialmotility
AT dahmliane erythropoietindampensinjuryinducedmicroglialmotility
AT heinrichralf erythropoietindampensinjuryinducedmicroglialmotility
AT monnheimermathieu erythropoietindampensinjuryinducedmicroglialmotility
AT gerhartsimone erythropoietindampensinjuryinducedmicroglialmotility
AT stegmullerjudith erythropoietindampensinjuryinducedmicroglialmotility
AT hanischuwekarsten erythropoietindampensinjuryinducedmicroglialmotility
AT naveklausarmin erythropoietindampensinjuryinducedmicroglialmotility
AT ehrenreichhannelore erythropoietindampensinjuryinducedmicroglialmotility

Ejemplares similares